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Statements

Subject Item
n2:RIV%2F60076658%3A12520%2F11%3A43872219%21RIV12-GA0-12520___
rdf:type
n11:Vysledek skos:Concept
dcterms:description
The study investigated the kinetics of p-nitrophenol hydroxylase (PNPH) in hepatic microsomes obtained from Atlantic salmon (Salmo salar). The selective inhibitors for some major mammalian cytochrome P450 (CYP450) were used to investigate the potential inhibitory effect on enzymes involved in p-nitrophenol hydroxylation. The following inhibitors were used: alfa-naphtoflavone (CYP1A), ellipticine (CYP1A1), furafylline (CYP1A2), 8-methoxypsoralen (8MOP, CYP2A6), 4-methylpyrazole (4MP, CYP2A6/2E1), diallyl sulfide (DAS, CYP2E1), and ketoconazole (CYP3A4). Additionally, the natural steroids 17-beta-oestraiol (E2) and testosterone were investigated as potential inhibitors of PNPH activity. Our results suggest that hepatic microsomes from Atlantic salmon possess CYP2E1-like activity. However, specific isoform-mediated PNPH activity should be identified. The study investigated the kinetics of p-nitrophenol hydroxylase (PNPH) in hepatic microsomes obtained from Atlantic salmon (Salmo salar). The selective inhibitors for some major mammalian cytochrome P450 (CYP450) were used to investigate the potential inhibitory effect on enzymes involved in p-nitrophenol hydroxylation. The following inhibitors were used: alfa-naphtoflavone (CYP1A), ellipticine (CYP1A1), furafylline (CYP1A2), 8-methoxypsoralen (8MOP, CYP2A6), 4-methylpyrazole (4MP, CYP2A6/2E1), diallyl sulfide (DAS, CYP2E1), and ketoconazole (CYP3A4). Additionally, the natural steroids 17-beta-oestraiol (E2) and testosterone were investigated as potential inhibitors of PNPH activity. Our results suggest that hepatic microsomes from Atlantic salmon possess CYP2E1-like activity. However, specific isoform-mediated PNPH activity should be identified.
dcterms:title
Para-nitrophenol hydroxylation by fish liver microsomes: kinetics and effect of selective cytochrome P450 inhibitors Para-nitrophenol hydroxylation by fish liver microsomes: kinetics and effect of selective cytochrome P450 inhibitors
skos:prefLabel
Para-nitrophenol hydroxylation by fish liver microsomes: kinetics and effect of selective cytochrome P450 inhibitors Para-nitrophenol hydroxylation by fish liver microsomes: kinetics and effect of selective cytochrome P450 inhibitors
skos:notation
RIV/60076658:12520/11:43872219!RIV12-GA0-12520___
n11:predkladatel
n13:orjk%3A12520
n3:aktivita
n15:S n15:P
n3:aktivity
P(ED2.1.00/01.0024), P(GAP503/11/1130), S
n3:cisloPeriodika
4
n3:dodaniDat
n5:2012
n3:domaciTvurceVysledku
n17:9855130
n3:druhVysledku
n16:J
n3:duvernostUdaju
n20:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
219571
n3:idVysledku
RIV/60076658:12520/11:43872219
n3:jazykVysledku
n9:eng
n3:klicovaSlova
P-nitrophenol; Hepatic microsomes; Ellipticine; Diallyl sulfide; Atlantic salmon
n3:klicoveSlovo
n4:P-nitrophenol n4:Hepatic%20microsomes n4:Atlantic%20salmon n4:Diallyl%20sulfide n4:Ellipticine
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[7A5F53109B15]
n3:nazevZdroje
Fish Physiology and Biochemistry
n3:obor
n19:CE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
2
n3:projekt
n7:ED2.1.00%2F01.0024 n7:GAP503%2F11%2F1130
n3:rokUplatneniVysledku
n5:2011
n3:svazekPeriodika
37
n3:tvurceVysledku
Žlábek, Vladimír Zamaratskaia, Galia
n3:wos
000296646800024
s:issn
0920-1742
s:numberOfPages
8
n14:doi
10.1007/s10695-011-9494-z
n10:organizacniJednotka
12520