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Statements

Subject Item
n2:RIV%2F60076658%3A12520%2F10%3A00011413%21RIV11-MZP-12520___
rdf:type
n11:Vysledek skos:Concept
dcterms:description
Recently, residual fungicides are generally recognized as relevant sources of aquatic environmental pollutants. However, the toxicological effects of these contaminants have not been adequately researched. In this study, the chronic effect of PCZ, a triazole-containing fungicide commonly present in aquatic environment, on GSH-related antioxidant system and oxidative stress indices of rainbow trout (Oncorhynchus mykiss) were investigated. Fish were exposed at sub-lethal concentrations of PCZ (0.2, 50 and 500 mu g/L) for 7, 20 and 30 days. GSH levels and GSH-related enzyme activities, including GPx, GR and GST, were quantified in three tissues liver, gill and muscle. The levels of LPO and CP were also measured as makers of oxidative damage. In addition, the correlations of the measured parameters in various tissues were evaluated by using PCA. The results of this study indicate that chronic exposure of PCZ has resulted in different responses in various tissues and the gill was the most sensitive tissue; Recently, residual fungicides are generally recognized as relevant sources of aquatic environmental pollutants. However, the toxicological effects of these contaminants have not been adequately researched. In this study, the chronic effect of PCZ, a triazole-containing fungicide commonly present in aquatic environment, on GSH-related antioxidant system and oxidative stress indices of rainbow trout (Oncorhynchus mykiss) were investigated. Fish were exposed at sub-lethal concentrations of PCZ (0.2, 50 and 500 mu g/L) for 7, 20 and 30 days. GSH levels and GSH-related enzyme activities, including GPx, GR and GST, were quantified in three tissues liver, gill and muscle. The levels of LPO and CP were also measured as makers of oxidative damage. In addition, the correlations of the measured parameters in various tissues were evaluated by using PCA. The results of this study indicate that chronic exposure of PCZ has resulted in different responses in various tissues and the gill was the most sensitive tissue;
dcterms:title
Modulation of glutathione-related antioxidant defense system of fish chronically treated by the fungicide propiconazole Modulation of glutathione-related antioxidant defense system of fish chronically treated by the fungicide propiconazole
skos:prefLabel
Modulation of glutathione-related antioxidant defense system of fish chronically treated by the fungicide propiconazole Modulation of glutathione-related antioxidant defense system of fish chronically treated by the fungicide propiconazole
skos:notation
RIV/60076658:12520/10:00011413!RIV11-MZP-12520___
n3:aktivita
n18:Z n18:P
n3:aktivity
P(SP/2E7/229/07), Z(MSM6007665809)
n3:cisloPeriodika
3
n3:dodaniDat
n8:2011
n3:domaciTvurceVysledku
n4:7985096 Li, Zhihua Li, Ping n4:9855130 n4:9002375
n3:druhVysledku
n19:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
272334
n3:idVysledku
RIV/60076658:12520/10:00011413
n3:jazykVysledku
n9:eng
n3:klicovaSlova
Fish; Oxidative stress; Residual fungicide; Glutathione
n3:klicoveSlovo
n12:Fish n12:Glutathione n12:Oxidative%20stress n12:Residual%20fungicide
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[979703E4B303]
n3:nazevZdroje
Comparative Biochemistry and Physiology C - Toxicology and Pharmacology
n3:obor
n15:GL
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n10:SP%2F2E7%2F229%2F07
n3:rokUplatneniVysledku
n8:2010
n3:svazekPeriodika
152
n3:tvurceVysledku
Grabic, Roman Randák, Tomáš Li, Zhihua Žlábek, Vladimír Li, Ping
n3:wos
000280902400020
n3:zamer
n5:MSM6007665809
s:issn
1532-0456
s:numberOfPages
7
n13:organizacniJednotka
12520