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Statements

Subject Item
n2:RIV%2F60076658%3A12520%2F09%3A00010321%21RIV10-MSM-12520___
rdf:type
n12:Vysledek skos:Concept
dcterms:description
The present study aimed to evaluate some cytochrome P450 metabolic enzyme activities in hepatic microsomes prepared from entire male pigs (uncastrated pigs), surgically castrated pigs and pigs immunized against gonadotropin-releasing hormone (immunocastrated pigs). The activities of the following enzymes were measured: ethoxyresorufin O-deethylase (EROD, CYP1A1/1A2), methoxyresorufin O-deethylase (MROD, CYP1A2), pentoxyresorufin O-depentylase (PROD, CYP2B), coumarin hydroxylase (COH, CYP2A) and p-nitrophenol hydroxylase (PNPH, CYP2A/2E1). The total cytochrome P450 contents were not affected by either surgical or immunocastration. Hepatic microsomal activities for EROD, PROD, COH and PNPH were lower in entire male pigs compared with surgically castrated and immunocastrated pigs ( P,0.05). Surgically and immunocastrated male pigs were similar with respect to EROD, MROD, PROD and COH activities ( P.0.05), whereas surgically castrated pigs exhibited lower PNPH activity compared with immunocastrated pigs ( The present study aimed to evaluate some cytochrome P450 metabolic enzyme activities in hepatic microsomes prepared from entire male pigs (uncastrated pigs), surgically castrated pigs and pigs immunized against gonadotropin-releasing hormone (immunocastrated pigs). The activities of the following enzymes were measured: ethoxyresorufin O-deethylase (EROD, CYP1A1/1A2), methoxyresorufin O-deethylase (MROD, CYP1A2), pentoxyresorufin O-depentylase (PROD, CYP2B), coumarin hydroxylase (COH, CYP2A) and p-nitrophenol hydroxylase (PNPH, CYP2A/2E1). The total cytochrome P450 contents were not affected by either surgical or immunocastration. Hepatic microsomal activities for EROD, PROD, COH and PNPH were lower in entire male pigs compared with surgically castrated and immunocastrated pigs ( P,0.05). Surgically and immunocastrated male pigs were similar with respect to EROD, MROD, PROD and COH activities ( P.0.05), whereas surgically castrated pigs exhibited lower PNPH activity compared with immunocastrated pigs (
dcterms:title
Modulation of porcine cytochrome P450 enzyme activities by surgical castration and immunocastration Modulation of porcine cytochrome P450 enzyme activities by surgical castration and immunocastration
skos:prefLabel
Modulation of porcine cytochrome P450 enzyme activities by surgical castration and immunocastration Modulation of porcine cytochrome P450 enzyme activities by surgical castration and immunocastration
skos:notation
RIV/60076658:12520/09:00010321!RIV10-MSM-12520___
n3:aktivita
n14:Z
n3:aktivity
Z(MSM6007665809)
n3:cisloPeriodika
3
n3:dodaniDat
n8:2010
n3:domaciTvurceVysledku
n16:9855130
n3:druhVysledku
n18:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
327185
n3:idVysledku
RIV/60076658:12520/09:00010321
n3:jazykVysledku
n4:eng
n3:klicovaSlova
Castration; cytochrome P450; porcine liver microsomes; steroids
n3:klicoveSlovo
n9:porcine%20liver%20microsomes n9:steroids n9:cytochrome%20P450 n9:Castration
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[505E029105E9]
n3:nazevZdroje
Animal
n3:obor
n17:FB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n8:2009
n3:svazekPeriodika
9
n3:tvurceVysledku
Madej, A. Chen, G. Žlábek, Vladimír Zamaratskaia, Galia
n3:wos
000268079600007
n3:zamer
n10:MSM6007665809
s:issn
1751-7311
s:numberOfPages
9
n15:organizacniJednotka
12520