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Statements

Subject Item
n2:RIV%2F60076658%3A12310%2F13%3A43886437%21RIV14-MSM-12310___
rdf:type
skos:Concept n9:Vysledek
rdfs:seeAlso
http://www.mdpi.com/1422-0067/14/2/3026
dcterms:description
Circadian rhythms are found in almost all organisms from cyanobacteria to humans, where most behavioral and physiological processes occur over a period of approximately 24 h in tandem with the day/night cycles. In general, these rhythmic processes are under regulation of circadian clocks. The role of circadian clocks in regulating metabolism and consequently cellular and metabolic homeostasis is an intensively investigated area of research. However, the links between circadian clocks and aging are correlative and only recently being investigated. A physiological decline in most processes is associated with advancing age, and occurs at the onset of maturity and in some instances is the result of accumulation of cellular damage beyond a critical level. A fully functional circadian clock would be vital to timing events in general metabolism, thus contributing to metabolic health and to ensure an increased %22health-span%22 during the process of aging. Here, we present recent evidence of links between clocks, cellular metabolism, aging and oxidative stress (one of the causative factors of aging). In the light of these data, we arrive at conceptual generalizations of this relationship across the spectrum of model organisms from fruit flies to mammals. Circadian rhythms are found in almost all organisms from cyanobacteria to humans, where most behavioral and physiological processes occur over a period of approximately 24 h in tandem with the day/night cycles. In general, these rhythmic processes are under regulation of circadian clocks. The role of circadian clocks in regulating metabolism and consequently cellular and metabolic homeostasis is an intensively investigated area of research. However, the links between circadian clocks and aging are correlative and only recently being investigated. A physiological decline in most processes is associated with advancing age, and occurs at the onset of maturity and in some instances is the result of accumulation of cellular damage beyond a critical level. A fully functional circadian clock would be vital to timing events in general metabolism, thus contributing to metabolic health and to ensure an increased %22health-span%22 during the process of aging. Here, we present recent evidence of links between clocks, cellular metabolism, aging and oxidative stress (one of the causative factors of aging). In the light of these data, we arrive at conceptual generalizations of this relationship across the spectrum of model organisms from fruit flies to mammals.
dcterms:title
Nature's Timepiece-Molecular Coordination of Metabolism and Its Impact on Aging Nature's Timepiece-Molecular Coordination of Metabolism and Its Impact on Aging
skos:prefLabel
Nature's Timepiece-Molecular Coordination of Metabolism and Its Impact on Aging Nature's Timepiece-Molecular Coordination of Metabolism and Its Impact on Aging
skos:notation
RIV/60076658:12310/13:43886437!RIV14-MSM-12310___
n9:predkladatel
n10:orjk%3A12310
n3:aktivita
n20:V
n3:aktivity
V
n3:cisloPeriodika
2
n3:dodaniDat
n17:2014
n3:domaciTvurceVysledku
n15:9631631 n15:4230930
n3:druhVysledku
n11:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
90865
n3:idVysledku
RIV/60076658:12310/13:43886437
n3:jazykVysledku
n13:eng
n3:klicovaSlova
reactive oxygen species; oxidative stress; metabolic hormones; homeostasis; cellular metabolism; circadian clocks; aging
n3:klicoveSlovo
n4:oxidative%20stress n4:homeostasis n4:aging n4:cellular%20metabolism n4:circadian%20clocks n4:reactive%20oxygen%20species n4:metabolic%20hormones
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[EB10427329F5]
n3:nazevZdroje
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
n3:obor
n8:ED
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
3
n3:rokUplatneniVysledku
n17:2013
n3:svazekPeriodika
14
n3:tvurceVysledku
Krishnan, Natraj Bednářová, Andrea Kodrík, Dalibor
n3:wos
000315397900045
s:issn
1422-0067
s:numberOfPages
24
n18:doi
10.3390/ijms14023026
n14:organizacniJednotka
12310