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Statements

Subject Item
n2:RIV%2F60076658%3A12310%2F06%3A00008791%21RIV08-MSM-12310___
rdf:type
n13:Vysledek skos:Concept
dcterms:description
Tetrahymena telomerase RNA (TER) contains several regions in addition to the template that are important for function. Central among these is the stem-loop IV domain, which is involved in both catalysis and RNP assembly, and includes binding sites for both the holoenzyme assembly protein p65 and telomerase reverse transcriptase (TERT). Stem-loop IV contains two regions with high evolutionary sequence conservation: a central GA bulge between helices, and a terminal loop. We solved the solution structure of loop IV and modeled the structure of the helical region containing the GA bulge, using NMR and residual dipolar couplings. The central GA bulge with flanking C-G base pairs induces a 50° semi-rigid bend in the helix. Loop IV is highly structured, and contains a conserved C-U base pair at the top of the helical stem. Analysis of new and previous biochemical data in light of the structure provides a rationale for some of the sequence conservation in this region of TER. The results suggest that during h Tetrahymena telomerase RNA (TER) contains several regions in addition to the template that are important for function. Central among these is the stem-loop IV domain, which is involved in both catalysis and RNP assembly, and includes binding sites for both the holoenzyme assembly protein p65 and telomerase reverse transcriptase (TERT). Stem-loop IV contains two regions with high evolutionary sequence conservation: a central GA bulge between helices, and a terminal loop. We solved the solution structure of loop IV and modeled the structure of the helical region containing the GA bulge, using NMR and residual dipolar couplings. The central GA bulge with flanking C-G base pairs induces a 50° semi-rigid bend in the helix. Loop IV is highly structured, and contains a conserved C-U base pair at the top of the helical stem. Analysis of new and previous biochemical data in light of the structure provides a rationale for some of the sequence conservation in this region of TER. The results suggest that during h Studium elementů struktury vlásenky IV telomerázové RNA z Tetrahymeny důležitých pro funkci.
dcterms:title
Structural study of elements of Tetrahymena telomerase RNA stem-loop IV domain important for function Studium elementů struktury vlásenky IV telomerázové RNA z Tetrahymeny důležitých pro funkci. Structural study of elements of Tetrahymena telomerase RNA stem-loop IV domain important for function
skos:prefLabel
Studium elementů struktury vlásenky IV telomerázové RNA z Tetrahymeny důležitých pro funkci. Structural study of elements of Tetrahymena telomerase RNA stem-loop IV domain important for function Structural study of elements of Tetrahymena telomerase RNA stem-loop IV domain important for function
skos:notation
RIV/60076658:12310/06:00008791!RIV08-MSM-12310___
n3:strany
1475-1485
n3:aktivita
n12:V
n3:aktivity
V
n3:cisloPeriodika
8
n3:dodaniDat
n9:2008
n3:domaciTvurceVysledku
n6:3971554
n3:druhVysledku
n16:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
501944
n3:idVysledku
RIV/60076658:12310/06:00008791
n3:jazykVysledku
n4:eng
n3:klicovaSlova
NMR; structure; GA bulge; p65; TER; TERT
n3:klicoveSlovo
n5:NMR n5:p65 n5:structure n5:GA%20bulge n5:TERT n5:TER
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[DE4FF156475E]
n3:nazevZdroje
RNA-A Publication of the RNA Society
n3:obor
n17:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n9:2006
n3:svazekPeriodika
12
n3:tvurceVysledku
O'Connor, Catherine Wu, Haihong Feigon, Juli Trantírek, Lukáš Collins, Kathleen Richards, Rebecca
s:issn
1355-8382
s:numberOfPages
11
n15:organizacniJednotka
12310