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Statements

Subject Item
n2:RIV%2F60076658%3A12220%2F10%3A00012564%21RIV11-MSM-12220___
rdf:type
skos:Concept n9:Vysledek
dcterms:description
The immune response in the stomach mucosa during the primary infection and re-infection with Cryptosporidium muris (TS03 and CB03) in immunocompetent BALB/c mice was characterized using flow cytometry analysis and measurement of IFN-gamma and IL10 by enzyme-linked immunosorbent assays (ELISA). Significantly, elevated migration of T lymphocytes (more than 1,000-fold), especially CD8+ T lymphocytes, to the stomach mucosa occurred during primary infection and persisted for more than 2 months after its resolution. The ex vivo cultures of splenocytes revealed very low levels of IFN-gamma production during the course of the primary infection (0.5 ng/ml), whereas in the following re-exposure to the parasites, the concentration of IFN-gamma rapidly increased 22-fold. These results imply that the CD8+ T lymphocytes are involved in the immune response to gastric cryptosporidiosis and could play an important role in the elimination of C. muris infection in mice. The immune response in the stomach mucosa during the primary infection and re-infection with Cryptosporidium muris (TS03 and CB03) in immunocompetent BALB/c mice was characterized using flow cytometry analysis and measurement of IFN-gamma and IL10 by enzyme-linked immunosorbent assays (ELISA). Significantly, elevated migration of T lymphocytes (more than 1,000-fold), especially CD8+ T lymphocytes, to the stomach mucosa occurred during primary infection and persisted for more than 2 months after its resolution. The ex vivo cultures of splenocytes revealed very low levels of IFN-gamma production during the course of the primary infection (0.5 ng/ml), whereas in the following re-exposure to the parasites, the concentration of IFN-gamma rapidly increased 22-fold. These results imply that the CD8+ T lymphocytes are involved in the immune response to gastric cryptosporidiosis and could play an important role in the elimination of C. muris infection in mice.
dcterms:title
Activation of protective cell-mediated immune response in gastric mucosa during Cryptosporidium muris infection and re-infection in immunocompetent mice Activation of protective cell-mediated immune response in gastric mucosa during Cryptosporidium muris infection and re-infection in immunocompetent mice
skos:prefLabel
Activation of protective cell-mediated immune response in gastric mucosa during Cryptosporidium muris infection and re-infection in immunocompetent mice Activation of protective cell-mediated immune response in gastric mucosa during Cryptosporidium muris infection and re-infection in immunocompetent mice
skos:notation
RIV/60076658:12220/10:00012564!RIV11-MSM-12220___
n4:aktivita
n7:V n7:Z n7:P n7:I
n4:aktivity
I, P(KJB500960701), V, Z(AV0Z60220518)
n4:cisloPeriodika
5
n4:dodaniDat
n18:2011
n4:domaciTvurceVysledku
n5:8524777
n4:druhVysledku
n12:J
n4:duvernostUdaju
n19:S
n4:entitaPredkladatele
n14:predkladatel
n4:idSjednocenehoVysledku
245280
n4:idVysledku
RIV/60076658:12220/10:00012564
n4:jazykVysledku
n11:eng
n4:klicovaSlova
Cryptosporidium muris; T-lymphocyte migration; gastric mucosa
n4:klicoveSlovo
n10:T-lymphocyte%20migration n10:Cryptosporidium%20muris n10:gastric%20mucosa
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[6575BCE38347]
n4:nazevZdroje
Parasitology Research
n4:obor
n17:GJ
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
6
n4:projekt
n16:KJB500960701
n4:rokUplatneniVysledku
n18:2010
n4:svazekPeriodika
106
n4:tvurceVysledku
Sak, Bohumil Květoňová, Dana Jalovecká, Marie Kučerová, Zuzana Salát, Jiří Kváč, Martin
n4:wos
000276234300021
n4:zamer
n8:AV0Z60220518
s:issn
0932-0113
s:numberOfPages
8
n6:organizacniJednotka
12220