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Statements

Subject Item
n2:RIV%2F60076658%3A12220%2F08%3A00009544%21RIV09-MZE-12220___
rdf:type
skos:Concept n18:Vysledek
dcterms:description
Factor XI (FIX) is a plasma serine protease involved in the early activation of the blood coagulation cascade. A survey of Holstein cattle, and Czech Simmental cattle crossed with Holstein, was done to determine whether animals heterozygous for FXI deficiency were present. Mutations in exon 12 and exon 9 were analysed. The method used was based on the polymerase chain reaction and subsequent distinction of the lenght of fragments.In the panel analysed (279 Holstein and 30 Simmentals), one heterozygous carrier of the recessive allele in exon 12 ( a German Holstein cow) was found. Some authors have found that the frequency is high in some breeding lines and low in others. Evidently the lines in our änalysis are part of the group with a low frequency. In exon 9, all the animals (100 Holstein and 52 Simmentals) were honozygous wild type. To date, the mutation in exon 9 has been found only in Japanese black cattle, and its breed-specific occurrence was therefore not disconfirmed by our assay. Our result Factor XI (FIX) is a plasma serine protease involved in the early activation of the blood coagulation cascade. A survey of Holstein cattle, and Czech Simmental cattle crossed with Holstein, was done to determine whether animals heterozygous for FXI deficiency were present. Mutations in exon 12 and exon 9 were analysed. The method used was based on the polymerase chain reaction and subsequent distinction of the lenght of fragments.In the panel analysed (279 Holstein and 30 Simmentals), one heterozygous carrier of the recessive allele in exon 12 ( a German Holstein cow) was found. Some authors have found that the frequency is high in some breeding lines and low in others. Evidently the lines in our änalysis are part of the group with a low frequency. In exon 9, all the animals (100 Holstein and 52 Simmentals) were honozygous wild type. To date, the mutation in exon 9 has been found only in Japanese black cattle, and its breed-specific occurrence was therefore not disconfirmed by our assay. Our result Faktor XI (FIX) je plazmová serinová proteáza, zahrnutá do časné aktivace kaskády krevní srážlivosti. Byl proveden průzkum u holštýnského skotu a kříženců českého strakatého skotu s holštýnským skotem s cílem stanovit, zda se zde vyskytují heterozygoti rpo deficiency FXI
dcterms:title
Sporadic incidence of factor XI deficiency in Holstein cattle Sporadic incidence of factor XI deficiency in Holstein cattle Ojedinělý výskyt deficience faktoru XI u holštýnského skotu
skos:prefLabel
Ojedinělý výskyt deficience faktoru XI u holštýnského skotu Sporadic incidence of factor XI deficiency in Holstein cattle Sporadic incidence of factor XI deficiency in Holstein cattle
skos:notation
RIV/60076658:12220/08:00009544!RIV09-MZE-12220___
n4:aktivita
n5:Z n5:S n5:P
n4:aktivity
P(QF3012), S, Z(MSM6007665806)
n4:cisloPeriodika
12
n4:dodaniDat
n9:2009
n4:domaciTvurceVysledku
n7:8004897 n7:7003293 n7:8398046
n4:druhVysledku
n19:J
n4:duvernostUdaju
n10:S
n4:entitaPredkladatele
n6:predkladatel
n4:idSjednocenehoVysledku
396628
n4:idVysledku
RIV/60076658:12220/08:00009544
n4:jazykVysledku
n17:eng
n4:klicovaSlova
Holstein; factor XI; exon 12; exon 9; PCR
n4:klicoveSlovo
n13:PCR n13:factor%20XI n13:Holstein n13:exon%2012 n13:exon%209
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[09CDD3EF43B1]
n4:nazevZdroje
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
n4:obor
n11:GJ
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
4
n4:projekt
n14:QF3012
n4:rokUplatneniVysledku
n9:2008
n4:svazekPeriodika
88
n4:tvurceVysledku
Čítek, Jindřich Řehout, Václav Hanusová, Lenka Vrabcová, P.
n4:wos
000262541700002
n4:zamer
n16:MSM6007665806
s:issn
0022-5142
s:numberOfPages
4
n15:organizacniJednotka
12220