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Statements

Subject Item
n2:RIV%2F60076658%3A12110%2F08%3A00009098%21RIV09-MSM-12110___
rdf:type
skos:Concept n15:Vysledek
dcterms:description
The circadian rhythms of the haemato-immune system seem to be synchronized by two clocks: the hypothalamic endogenous, and the exogenous which is based on environmental stimuli. The suprachiasmatic nucleus is not only a circadian clock, it also synchronizes peripheral oscillators and integrates light information through the retino-hypothalamic tract. The role of the ?peripheral? clock genes in mature leucocytes still remains an unanswered question as well as the role of clock proteins in ?non-clock? physiology. The circadian rhythms may be a basis for circannual variations, although the molecular bases of such rhythms remain a mystery. There are several hormones which have a significant impact on haematological characteristics; the finding of a lower superoxide release from granulocytes at higher melatonin levels opens up new research opportunities for melatonin therapy. Discrepancies between circadian changes in mRNAs and the appropriate protein participating in haemocoagulation and fibrinolysis may Přehledný článek věnovaný pokrokům v chronohematologii v posledních letech. Jsou nastoleny otázky týkající se hematoimunitního systému, jeho regulace na urovni celého organismu i na úrovn aktivity genů. Problematika regulace biorytmů při hemokoagulaci a fibrinolýze zůstává stále ve velké míře neobjasněna. Endogenní složka rytmů usnadňuje reparativní procesy během subjektivní noci. The circadian rhythms of the haemato-immune system seem to be synchronized by two clocks: the hypothalamic endogenous, and the exogenous which is based on environmental stimuli. The suprachiasmatic nucleus is not only a circadian clock, it also synchronizes peripheral oscillators and integrates light information through the retino-hypothalamic tract. The role of the ?peripheral? clock genes in mature leucocytes still remains an unanswered question as well as the role of clock proteins in ?non-clock? physiology. The circadian rhythms may be a basis for circannual variations, although the molecular bases of such rhythms remain a mystery. There are several hormones which have a significant impact on haematological characteristics; the finding of a lower superoxide release from granulocytes at higher melatonin levels opens up new research opportunities for melatonin therapy. Discrepancies between circadian changes in mRNAs and the appropriate protein participating in haemocoagulation and fibrinolysis may
dcterms:title
Advances in chronohaematology Advances in chronohaematology Pokroky v chronohematologii
skos:prefLabel
Advances in chronohaematology Advances in chronohaematology Pokroky v chronohematologii
skos:notation
RIV/60076658:12110/08:00009098!RIV09-MSM-12110___
n3:aktivita
n7:V
n3:aktivity
V
n3:cisloPeriodika
2
n3:dodaniDat
n5:2009
n3:domaciTvurceVysledku
n11:6727948
n3:druhVysledku
n16:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
355012
n3:idVysledku
RIV/60076658:12110/08:00009098
n3:jazykVysledku
n14:eng
n3:klicovaSlova
circadian; seasonal; clock gene; haemostasis; immunity; melatonin; superoxide
n3:klicoveSlovo
n9:haemostasis n9:clock%20gene n9:melatonin n9:superoxide n9:circadian n9:seasonal n9:immunity
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[DF65E0C6D546]
n3:nazevZdroje
Journal of Applied Biomedicine
n3:obor
n13:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
1
n3:rokUplatneniVysledku
n5:2008
n3:svazekPeriodika
6
n3:tvurceVysledku
Berger, Josef
s:issn
1214-021X
s:numberOfPages
8
n12:organizacniJednotka
12110