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Statements

Subject Item
n2:RIV%2F49777513%3A23520%2F09%3A00501877%21RIV10-MSM-23520___
rdf:type
skos:Concept n14:Vysledek
dcterms:description
Long-term hypertension in arteries leads to remodelling of the arterial wall. We focused on morphological changes in the wall of the subrenal aorta in rats suffering from arterial hypertension and chronic renal failure induced by 5/6 nephrectomy (NX). We quantified the area of the profile of the arterial lumen, the volume fraction of elastin and smooth muscle cells (SMC) in the tunica media, the thickness of the intima-media, the length density of elastin lamellae, the lamellar unit thickness and the lamellar number. Calcitonin gene related peptide (CGRP) was assayed in extracts of aortic tissue and in plasma. Ten days after the subtotal nephrectomy, the structure of the aorta of NX rats did not differ compared to control animals. Pronounced structural changes were observed ten weeks after 5/6 nephrectomy. The area of the lumen profile, the elastin volume fraction and the elastin lamellar number in the tunica media were all significantly higher (p < 0.001) in NX than in control animals. The SMC vo Long-term hypertension in arteries leads to remodelling of the arterial wall. We focused on morphological changes in the wall of the subrenal aorta in rats suffering from arterial hypertension and chronic renal failure induced by 5/6 nephrectomy (NX). We quantified the area of the profile of the arterial lumen, the volume fraction of elastin and smooth muscle cells (SMC) in the tunica media, the thickness of the intima-media, the length density of elastin lamellae, the lamellar unit thickness and the lamellar number. Calcitonin gene related peptide (CGRP) was assayed in extracts of aortic tissue and in plasma. Ten days after the subtotal nephrectomy, the structure of the aorta of NX rats did not differ compared to control animals. Pronounced structural changes were observed ten weeks after 5/6 nephrectomy. The area of the lumen profile, the elastin volume fraction and the elastin lamellar number in the tunica media were all significantly higher (p < 0.001) in NX than in control animals. The SMC vo
dcterms:title
Aorta remodelling associated with calcitonin gene related peptide concentration in rats with arterial hypertension Aorta remodelling associated with calcitonin gene related peptide concentration in rats with arterial hypertension
skos:prefLabel
Aorta remodelling associated with calcitonin gene related peptide concentration in rats with arterial hypertension Aorta remodelling associated with calcitonin gene related peptide concentration in rats with arterial hypertension
skos:notation
RIV/49777513:23520/09:00501877!RIV10-MSM-23520___
n3:aktivita
n17:P n17:Z
n3:aktivity
P(1M0510), P(GA106/09/0734), Z(MSM0021620819), Z(MSM4977751303)
n3:cisloPeriodika
4
n3:dodaniDat
n13:2010
n3:domaciTvurceVysledku
n4:8036519 n4:4948289
n3:druhVysledku
n16:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
303574
n3:idVysledku
RIV/49777513:23520/09:00501877
n3:jazykVysledku
n11:eng
n3:klicovaSlova
histology; stereology; chronic renal failure; nephrectomy; quantitative microscopy
n3:klicoveSlovo
n10:quantitative%20microscopy n10:nephrectomy n10:stereology n10:chronic%20renal%20failure n10:histology
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[6DA2926C844F]
n3:nazevZdroje
Acta Veterinaria Brno
n3:obor
n15:EA
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
6
n3:projekt
n18:GA106%2F09%2F0734 n18:1M0510
n3:rokUplatneniVysledku
n13:2009
n3:svazekPeriodika
78
n3:tvurceVysledku
Švíglerová, Jitka Štengl, Milan Tonar, Zbyněk Matějka, Vít M. Kuncová, Jitka Kochová, Petra
n3:zamer
n8:MSM4977751303 n8:MSM0021620819
s:issn
0001-7213
s:numberOfPages
8
n9:organizacniJednotka
23520