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Statements

Subject Item
n2:RIV%2F44555601%3A13440%2F14%3A43885156%21RIV15-MSM-13440___
rdf:type
n11:Vysledek skos:Concept
dcterms:description
Cationic carbosilane dendrimers of generations 1-3 have been synthesized employing thiol-ene click chemistry. The obtained dendrimers present three different types of ammonium functions, two of them with the charge at the surface, -NH3 + and -NMe3 +, and other with the charge internalized by the presence of ethylalcohol moieties, -[NMe2(CH2CH2OH)]+. The influence of -NMe3 + and -[NMe2(CH2CH2OH)]+ in dendrimer structure have been studied by molecular dynamics. The antibacterial properties of these families of dendrimers have been evaluated against Gram-positive (Staphylococcus aureus CECT 240) and Gramnegative (Escherichia coli CECT 515) bacterial strains, and the results have been compared with those obtained for related cationic carbosilane dendrimers functionalized by hydrosilylation reactions. These data show the relevance of the sulfur atom versus the silicon atom close to the dendrimer surface and the outer charge versus the inner charge. Finally, the stability of the most active first generation dendrimers vs. pH and temperature has also been studied. Cationic carbosilane dendrimers of generations 1-3 have been synthesized employing thiol-ene click chemistry. The obtained dendrimers present three different types of ammonium functions, two of them with the charge at the surface, -NH3 + and -NMe3 +, and other with the charge internalized by the presence of ethylalcohol moieties, -[NMe2(CH2CH2OH)]+. The influence of -NMe3 + and -[NMe2(CH2CH2OH)]+ in dendrimer structure have been studied by molecular dynamics. The antibacterial properties of these families of dendrimers have been evaluated against Gram-positive (Staphylococcus aureus CECT 240) and Gramnegative (Escherichia coli CECT 515) bacterial strains, and the results have been compared with those obtained for related cationic carbosilane dendrimers functionalized by hydrosilylation reactions. These data show the relevance of the sulfur atom versus the silicon atom close to the dendrimer surface and the outer charge versus the inner charge. Finally, the stability of the most active first generation dendrimers vs. pH and temperature has also been studied.
dcterms:title
Carbosilane cationic dendrimers synthesized by thiol-ene click chemistry and their use as antibacterial agents Carbosilane cationic dendrimers synthesized by thiol-ene click chemistry and their use as antibacterial agents
skos:prefLabel
Carbosilane cationic dendrimers synthesized by thiol-ene click chemistry and their use as antibacterial agents Carbosilane cationic dendrimers synthesized by thiol-ene click chemistry and their use as antibacterial agents
skos:notation
RIV/44555601:13440/14:43885156!RIV15-MSM-13440___
n3:aktivita
n13:I
n3:aktivity
I
n3:cisloPeriodika
3
n3:dodaniDat
n8:2015
n3:domaciTvurceVysledku
n5:2991098
n3:druhVysledku
n14:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
6223
n3:idVysledku
RIV/44555601:13440/14:43885156
n3:jazykVysledku
n10:eng
n3:klicovaSlova
HIV; salts; polymers; efficient; transfection; complexation; ThioEther dendrimers; antimicobial activity; Ammonium; Quaternary
n3:klicoveSlovo
n7:polymers n7:antimicobial%20activity n7:Ammonium n7:HIV n7:Quaternary n7:efficient n7:complexation n7:salts n7:transfection n7:ThioEther%20dendrimers
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[BAA7A4C1111B]
n3:nazevZdroje
RSC Advances
n3:obor
n9:CC
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
11
n3:rokUplatneniVysledku
n8:2014
n3:svazekPeriodika
4
n3:tvurceVysledku
Fuentes-Paniagua, Elena Rafae, Gómez Juan, Soliveri Sánchez-Milla, Maria Copa-Patino, José Luis Camero, M. Alejandra Sánchez-Nieves, Javier de la Mata, F. J. Hernández-Ros, José Manuel Malý, Marek Pérez-Serrano, Jorge
n3:wos
000327868400035
s:issn
2046-2069
s:numberOfPages
10
n12:doi
10.1039/c3ra45408h
n18:organizacniJednotka
13440