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Statements

Subject Item
n2:RIV%2F44555601%3A13440%2F12%3A43884042%21RIV13-MSM-13440___
rdf:type
n9:Vysledek skos:Concept
dcterms:description
Dendrimers are artificial polymeric macromolecules which are widely considered to be a promising tool for future gene therapy applications. They have been used as efficient delivery vehicles for antisense oligonucleotides targeting the interior of cells. We demonstrate that dendriplexes formed from anti-HIV oligodeoxynucleotides ANTI-TAR, GEM91, and SREV in complex with generation 4 maltose (PPI-Mal G4) and maltotriose (PPI-Mal-III G4) modified poly(propylene imine) dendrimers are able to self-assemble into highly organized 1D and 3D nanostructures. The resulting nanostructures were characterized by fluorescence methods, laser Doppler electrophoresis, dynamic light scattering (DLS), atomic force microscopy (AFM) and molecular modeling. The results show that ANTI-TAR and GEM 91 dendriplexes self-assemble into fibrils with length scales up to several hundreds of nm. SREV, on the contrary, forms quadrilateral- like 3D nanostructures. A good correlation between the various experimental methods and molecular modeling indicates the formation of those nanostructures in solution. Space symmetry of the oligonucleotides and the resulting dendriplex monomeric units are probably the most important factors which influence the way of self-assembling. Dendrimers are artificial polymeric macromolecules which are widely considered to be a promising tool for future gene therapy applications. They have been used as efficient delivery vehicles for antisense oligonucleotides targeting the interior of cells. We demonstrate that dendriplexes formed from anti-HIV oligodeoxynucleotides ANTI-TAR, GEM91, and SREV in complex with generation 4 maltose (PPI-Mal G4) and maltotriose (PPI-Mal-III G4) modified poly(propylene imine) dendrimers are able to self-assemble into highly organized 1D and 3D nanostructures. The resulting nanostructures were characterized by fluorescence methods, laser Doppler electrophoresis, dynamic light scattering (DLS), atomic force microscopy (AFM) and molecular modeling. The results show that ANTI-TAR and GEM 91 dendriplexes self-assemble into fibrils with length scales up to several hundreds of nm. SREV, on the contrary, forms quadrilateral- like 3D nanostructures. A good correlation between the various experimental methods and molecular modeling indicates the formation of those nanostructures in solution. Space symmetry of the oligonucleotides and the resulting dendriplex monomeric units are probably the most important factors which influence the way of self-assembling.
dcterms:title
Highly Organized Self-Assembled Dendriplexes Based on Poly(propylene imine) Glycodendrimer and Anti-HIV Oligodeoxynucleotides Highly Organized Self-Assembled Dendriplexes Based on Poly(propylene imine) Glycodendrimer and Anti-HIV Oligodeoxynucleotides
skos:prefLabel
Highly Organized Self-Assembled Dendriplexes Based on Poly(propylene imine) Glycodendrimer and Anti-HIV Oligodeoxynucleotides Highly Organized Self-Assembled Dendriplexes Based on Poly(propylene imine) Glycodendrimer and Anti-HIV Oligodeoxynucleotides
skos:notation
RIV/44555601:13440/12:43884042!RIV13-MSM-13440___
n9:predkladatel
n10:orjk%3A13440
n3:aktivita
n6:S n6:P
n3:aktivity
P(OC10053), S
n3:cisloPeriodika
27
n3:dodaniDat
n16:2013
n3:domaciTvurceVysledku
n8:2991098 n8:2400618 n8:6021875
n3:druhVysledku
n11:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
139014
n3:idVysledku
RIV/44555601:13440/12:43884042
n3:jazykVysledku
n18:eng
n3:klicovaSlova
Antisense therapy, atomic force microscopy, dendriplexes, molecular modeling, nanofibers, PPI dendrimers, self-assembling, dynamic light scattering, anti-HIV therapy, drug delivery.
n3:klicoveSlovo
n4:nanofibers n4:anti-HIV%20therapy n4:dendriplexes n4:Antisense%20therapy n4:PPI%20dendrimers n4:dynamic%20light%20scattering n4:drug%20delivery. n4:atomic%20force%20microscopy n4:self-assembling n4:molecular%20modeling
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[6DF0EB24D592]
n3:nazevZdroje
Current Medicinal Chemistry
n3:obor
n17:BO
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
9
n3:projekt
n13:OC10053
n3:rokUplatneniVysledku
n16:2012
n3:svazekPeriodika
19
n3:tvurceVysledku
Zaborski, M. Malý, Marek Klajnert, B. Pedziwiatr-Werbicka, E. Danani, A. Malý, Jan Semerádtová, Alena Bryszewska, M. Appelhans, D.
n3:wos
000309718800018
s:issn
0929-8673
s:numberOfPages
12
n20:doi
10.2174/092986712803306457
n19:organizacniJednotka
13440