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Statements

Subject Item
n2:RIV%2F44555601%3A13440%2F12%3A43883963%21RIV13-MSM-13440___
rdf:type
skos:Concept n17:Vysledek
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/S0168365912004439
dcterms:description
Researchers have been working hard for more than 20 years to develop safe and effective microbicides to empower women to better control their own sexual life and to protect themselves against HIV and other sexually transmitted infections (STIs). Microbicide classes include moderately specific macromolecular anionic polymers that block HIV and other STIs, and HIV specific drugs that inhibit viral entry and reverse transcription. Based on innovative nanotechnology design,we showed a novelwater-soluble anionic carbosilane dendrimer (2G-S16) as a propitious molecule against HIV-infection. A state-of-the-art research was accomplished that focused on biomedical cutting-edge techniques such as in vitro and in vivo cytotoxicity assays performed on female rabbit genital tracts, simulate in vitro model of vaginal epithelium in order to evaluate HIV transmission blockade through the monolayer, complete gene expression profiling experiment to study deregulated genes after 2G-S16 exposition, molecular dynamics simulation of 2G-S16 molecule against principal proteins of HIV particles and pro- and anti-inflammatory cytokine profile study. Therefore, a high-throughput study and detailed analysis of the results were achieved in this article. We provided promising outcomes to encourage 2G-S16 as a hopeful microbicide. Researchers have been working hard for more than 20 years to develop safe and effective microbicides to empower women to better control their own sexual life and to protect themselves against HIV and other sexually transmitted infections (STIs). Microbicide classes include moderately specific macromolecular anionic polymers that block HIV and other STIs, and HIV specific drugs that inhibit viral entry and reverse transcription. Based on innovative nanotechnology design,we showed a novelwater-soluble anionic carbosilane dendrimer (2G-S16) as a propitious molecule against HIV-infection. A state-of-the-art research was accomplished that focused on biomedical cutting-edge techniques such as in vitro and in vivo cytotoxicity assays performed on female rabbit genital tracts, simulate in vitro model of vaginal epithelium in order to evaluate HIV transmission blockade through the monolayer, complete gene expression profiling experiment to study deregulated genes after 2G-S16 exposition, molecular dynamics simulation of 2G-S16 molecule against principal proteins of HIV particles and pro- and anti-inflammatory cytokine profile study. Therefore, a high-throughput study and detailed analysis of the results were achieved in this article. We provided promising outcomes to encourage 2G-S16 as a hopeful microbicide.
dcterms:title
Carbosilane dendrimer nanotechnology outlines of the broad HIV blocker profile Carbosilane dendrimer nanotechnology outlines of the broad HIV blocker profile
skos:prefLabel
Carbosilane dendrimer nanotechnology outlines of the broad HIV blocker profile Carbosilane dendrimer nanotechnology outlines of the broad HIV blocker profile
skos:notation
RIV/44555601:13440/12:43883963!RIV13-MSM-13440___
n17:predkladatel
n18:orjk%3A13440
n3:aktivita
n10:P
n3:aktivity
P(OC10053)
n3:cisloPeriodika
3
n3:dodaniDat
n6:2013
n3:domaciTvurceVysledku
n16:2991098
n3:druhVysledku
n9:J
n3:duvernostUdaju
n20:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
125982
n3:idVysledku
RIV/44555601:13440/12:43883963
n3:jazykVysledku
n7:eng
n3:klicovaSlova
molecular modeling; biocompatibility; Anti-HIV activity; microbicide; Dendrimer
n3:klicoveSlovo
n4:molecular%20modeling n4:Dendrimer n4:Anti-HIV%20activity n4:biocompatibility n4:microbicide
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[4CC505F66167]
n3:nazevZdroje
Journal of Controlled Release
n3:obor
n15:EE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
11
n3:projekt
n5:OC10053
n3:rokUplatneniVysledku
n6:2012
n3:svazekPeriodika
161
n3:tvurceVysledku
Gómez, R. Pion, M. Rasines, B. De la Mata, J. Chonco, L. Alvarez, S. López-Fernándes, L. Mu?oz-Fernández, M. A. Serramía, M. J. Malý, Marek Vacas, E.
n3:wos
000308077000029
s:issn
0168-3659
s:numberOfPages
10
n14:doi
10.1016/j.jconrel.2012.04.050
n13:organizacniJednotka
13440