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Statements

Subject Item
n2:RIV%2F26722445%3A_____%2F11%3A%230000651%21RIV12-MPO-26722445
rdf:type
n12:Vysledek skos:Concept
dcterms:description
Interaction of epithermal neutrons with boron-10 (10B) leads to a damage of tumor tissue conferred (circumscribed) even soliatary cells. The nuclear reactors used for tumor therapy (Boron-Neutron-Capture-Therapy, BNCT) require individual tuning and monitoring by physical and biological methods. Here, were report effects of epithermal beam of the LVR-15 in Řež (7.8x 108n/cm2, 9 MW, 16.1 cGy/min) on the immature rat brain and C6 glioma culture, the model developed by us for this purpose (Mares et al. 1997, Burian et al. Kagawa). Irradiation of animals for 4 to 7 minutes induced the dose- and the cell differentiation degree- dependent apoptosis-like death in the cerebellum and forebrain, exceeding 2.1 times a gamma radiation equivalent. 3 days later, a dose inverse regeneration was evident in the cerebellum. In cultures irradiated for 30 to 45 min, the cells slowed-down cycling and cell death reaching a peak value at 72 to 96 h. Interaction of epithermal neutrons with boron-10 (10B) leads to a damage of tumor tissue conferred (circumscribed) even soliatary cells. The nuclear reactors used for tumor therapy (Boron-Neutron-Capture-Therapy, BNCT) require individual tuning and monitoring by physical and biological methods. Here, were report effects of epithermal beam of the LVR-15 in Řež (7.8x 108n/cm2, 9 MW, 16.1 cGy/min) on the immature rat brain and C6 glioma culture, the model developed by us for this purpose (Mares et al. 1997, Burian et al. Kagawa). Irradiation of animals for 4 to 7 minutes induced the dose- and the cell differentiation degree- dependent apoptosis-like death in the cerebellum and forebrain, exceeding 2.1 times a gamma radiation equivalent. 3 days later, a dose inverse regeneration was evident in the cerebellum. In cultures irradiated for 30 to 45 min, the cells slowed-down cycling and cell death reaching a peak value at 72 to 96 h.
dcterms:title
The cell damage and regeneration in the immature brain and glioma cultures irradiated by epithermal neutron beam of the LVR-15 nuclear reactor in Řež The cell damage and regeneration in the immature brain and glioma cultures irradiated by epithermal neutron beam of the LVR-15 nuclear reactor in Řež
skos:prefLabel
The cell damage and regeneration in the immature brain and glioma cultures irradiated by epithermal neutron beam of the LVR-15 nuclear reactor in Řež The cell damage and regeneration in the immature brain and glioma cultures irradiated by epithermal neutron beam of the LVR-15 nuclear reactor in Řež
skos:notation
RIV/26722445:_____/11:#0000651!RIV12-MPO-26722445
n12:predkladatel
n21:ico%3A26722445
n3:aktivita
n13:P
n3:aktivity
P(FR-TI1/378)
n3:dodaniDat
n6:2012
n3:domaciTvurceVysledku
n9:4194365 n9:3753115
n3:druhVysledku
n10:D
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
189372
n3:idVysledku
RIV/26722445:_____/11:#0000651
n3:jazykVysledku
n8:eng
n3:klicovaSlova
Boron-Neutron-Capture-Therapy
n3:klicoveSlovo
n17:Boron-Neutron-Capture-Therapy
n3:kontrolniKodProRIV
[E11FCC4EE343]
n3:mistoKonaniAkce
Plzeň
n3:mistoVydani
Plzeň
n3:nazevZdroje
XX. Biologické dny : Kmenové buňky – od regenerativní medicíny k nádorové biologii
n3:obor
n4:BG
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
5
n3:projekt
n14:FR-TI1%2F378
n3:rokUplatneniVysledku
n6:2011
n3:tvurceVysledku
Marek, Milan Burian, Jiří
n3:typAkce
n16:CST
n3:zahajeniAkce
2011-01-01+01:00
s:numberOfPages
2
n18:hasPublisher
Československá biologická společnost a Lékařská fakulta UK v Plzni
n15:isbn
9788026008491