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Statements

Subject Item
n2:RIV%2F26475821%3A_____%2F13%3A%230000191%21RIV14-MZ0-26475821
rdf:type
skos:Concept n14:Vysledek
dcterms:description
Poster presenting clinical utility of molecular characterization of gastric cancer. According to the Czech national cancer register the prognosis of gastric cancer patients has remained unchanged over the course of the past 20 years. With a 5-year survival of just 30% (for all stages) it is the third most fatal malignancy of the gastrointestinal tract and sixth overall among solid cancers. The recent trends in discovery and use of biomarkers in other cancers have been mainly derived from detailed tumor profiling. Somatic mutations and gene amplifications are among the molecular aberations frequently studied. The conclusion is: Somatic mutations are not associated with localization or stage and are likely not factors in prognosis of the disease. Molecular classification of gastric cancer based on gene amplification patterns results in distinct tumor similarities that may have clinical relevance for clinical management of gastric cancer. Poster presenting clinical utility of molecular characterization of gastric cancer. According to the Czech national cancer register the prognosis of gastric cancer patients has remained unchanged over the course of the past 20 years. With a 5-year survival of just 30% (for all stages) it is the third most fatal malignancy of the gastrointestinal tract and sixth overall among solid cancers. The recent trends in discovery and use of biomarkers in other cancers have been mainly derived from detailed tumor profiling. Somatic mutations and gene amplifications are among the molecular aberations frequently studied. The conclusion is: Somatic mutations are not associated with localization or stage and are likely not factors in prognosis of the disease. Molecular classification of gastric cancer based on gene amplification patterns results in distinct tumor similarities that may have clinical relevance for clinical management of gastric cancer.
dcterms:title
CLINICAL UTILITY OF MOLECULAR CHARACTERIZATION OF GASTRIC CANCERS BASED ON SOMATIC MUTATIONS AND GENE AMPLIFICATIONS CLINICAL UTILITY OF MOLECULAR CHARACTERIZATION OF GASTRIC CANCERS BASED ON SOMATIC MUTATIONS AND GENE AMPLIFICATIONS
skos:prefLabel
CLINICAL UTILITY OF MOLECULAR CHARACTERIZATION OF GASTRIC CANCERS BASED ON SOMATIC MUTATIONS AND GENE AMPLIFICATIONS CLINICAL UTILITY OF MOLECULAR CHARACTERIZATION OF GASTRIC CANCERS BASED ON SOMATIC MUTATIONS AND GENE AMPLIFICATIONS
skos:notation
RIV/26475821:_____/13:#0000191!RIV14-MZ0-26475821
n14:predkladatel
n15:ico%3A26475821
n3:aktivita
n5:P
n3:aktivity
P(NT13640)
n3:dodaniDat
n4:2014
n3:domaciTvurceVysledku
n10:7377061 n10:2689677 n10:6636365
n3:druhVysledku
n9:O
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
65708
n3:idVysledku
RIV/26475821:_____/13:#0000191
n3:jazykVysledku
n16:eng
n3:klicovaSlova
APC, CTNNB1, KRAS, BRAF, EGFR, PIK3CA, TP53
n3:klicoveSlovo
n8:CTNNB1 n8:BRAF n8:APC n8:KRAS n8:PIK3CA n8:EGFR n8:TP53
n3:kontrolniKodProRIV
[BFC94A3E3B0A]
n3:obor
n13:EB
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
8
n3:projekt
n7:NT13640
n3:rokUplatneniVysledku
n4:2013
n3:tvurceVysledku
Minárik, Marek Belšánová, Barbora Benešová, Lucie