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Statements

Subject Item
n2:RIV%2F00843989%3A_____%2F13%3A00103181%21RIV14-MZ0-00843989
rdf:type
n10:Vysledek skos:Concept
dcterms:description
Knowledge of differences in human papillomavirus (HPV)-type prevalence between high-grade cervical intraepithelial neoplasia (HG-CIN) and invasive cervical cancer (ICC) is crucial for understanding the natural history of HPV-infected cervical lesions and the potential impact of HPV vaccination on cervical cancer prevention. More than 6,000 women diagnosed with HG-CIN or ICC from 17 European countries were enrolled in two parallel cross-sectional studies (108288/108290). Centralised histopathology review and standardised HPV-DNA typing were applied to formalin-fixed paraffin-embedded cervical specimens dated 2001-2008. The pooled prevalence of individual HPV types was estimated using meta-analytic methods. A total of 3,103 women were diagnosed with HG-CIN and a total of 3,162 with ICC (median ages: 34 and 49 years, respectively), of which 98.5 and 91.8% were HPV-positive, respectively. The most common HPV types in women with HG-CIN were HPV16/33/31 (59.9/10.5/9.0%) and in ICC were HPV16/18/45 (63.3/15.2/5.3%). In squamous cell carcinomas, HPV16/18/33 were most frequent (66.2/10.8/5.3%), and in adenocarcinomas, HPV16/18/45 (54.2/40.4/ 8.3%). The prevalence of HPV16/18/45 was 1.1/3.5/2.5 times higher in ICC than in HG-CIN. The difference in age at diagnosis between CIN3 and squamous cervical cancer for HPV18 (9 years) was significantly less compared to HPV31/33/ 'other' (23/20/17 years), and for HPV45 (1 year) than HPV16/31/33/'other' (15/23/20/17 years). In Europe, HPV16 predominates in both HG-CIN and ICC, whereas HPV18/45 are associated with a low median age of ICC. HPV18/45 are more frequent in ICC than HG-CIN and associated with a high median age of HG-CIN, with a narrow age interval between HG-CIN and ICC detection. These findings support the need for primary prevention of HPV16/18/45-related cervical lesions. Knowledge of differences in human papillomavirus (HPV)-type prevalence between high-grade cervical intraepithelial neoplasia (HG-CIN) and invasive cervical cancer (ICC) is crucial for understanding the natural history of HPV-infected cervical lesions and the potential impact of HPV vaccination on cervical cancer prevention. More than 6,000 women diagnosed with HG-CIN or ICC from 17 European countries were enrolled in two parallel cross-sectional studies (108288/108290). Centralised histopathology review and standardised HPV-DNA typing were applied to formalin-fixed paraffin-embedded cervical specimens dated 2001-2008. The pooled prevalence of individual HPV types was estimated using meta-analytic methods. A total of 3,103 women were diagnosed with HG-CIN and a total of 3,162 with ICC (median ages: 34 and 49 years, respectively), of which 98.5 and 91.8% were HPV-positive, respectively. The most common HPV types in women with HG-CIN were HPV16/33/31 (59.9/10.5/9.0%) and in ICC were HPV16/18/45 (63.3/15.2/5.3%). In squamous cell carcinomas, HPV16/18/33 were most frequent (66.2/10.8/5.3%), and in adenocarcinomas, HPV16/18/45 (54.2/40.4/ 8.3%). The prevalence of HPV16/18/45 was 1.1/3.5/2.5 times higher in ICC than in HG-CIN. The difference in age at diagnosis between CIN3 and squamous cervical cancer for HPV18 (9 years) was significantly less compared to HPV31/33/ 'other' (23/20/17 years), and for HPV45 (1 year) than HPV16/31/33/'other' (15/23/20/17 years). In Europe, HPV16 predominates in both HG-CIN and ICC, whereas HPV18/45 are associated with a low median age of ICC. HPV18/45 are more frequent in ICC than HG-CIN and associated with a high median age of HG-CIN, with a narrow age interval between HG-CIN and ICC detection. These findings support the need for primary prevention of HPV16/18/45-related cervical lesions.
dcterms:title
Differences in human papillomavirus type distribution in high-grade cervical intraepithelial neoplasia and invasive cervical cancer in Europe Differences in human papillomavirus type distribution in high-grade cervical intraepithelial neoplasia and invasive cervical cancer in Europe
skos:prefLabel
Differences in human papillomavirus type distribution in high-grade cervical intraepithelial neoplasia and invasive cervical cancer in Europe Differences in human papillomavirus type distribution in high-grade cervical intraepithelial neoplasia and invasive cervical cancer in Europe
skos:notation
RIV/00843989:_____/13:00103181!RIV14-MZ0-00843989
n10:predkladatel
n11:ico%3A00843989
n3:aktivita
n17:N
n3:aktivity
N
n3:cisloPeriodika
n. 4
n3:dodaniDat
n7:2014
n3:domaciTvurceVysledku
n16:7095066 n16:6196632
n3:druhVysledku
n15:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
69599
n3:idVysledku
RIV/00843989:_____/13:00103181
n3:jazykVysledku
n4:eng
n3:klicovaSlova
human papillomavirus; HPV; cervical cancer; cervical intraepithelial neoplasia; CIN
n3:klicoveSlovo
n9:CIN n9:cervical%20cancer n9:HPV n9:cervical%20intraepithelial%20neoplasia n9:human%20papillomavirus
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[455C18D3F045]
n3:nazevZdroje
International journal of cancer
n3:obor
n5:FD
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
116
n3:rokUplatneniVysledku
n7:2013
n3:svazekPeriodika
132
n3:tvurceVysledku
Molijn, A. Raillard, A. Vladareanu, R. Collas De Souza, S. Joura, E. A. Kolomiets, L. Damaskou, V. O´Leary, J. Tjalma, W. A. Fiander, A. Koiss, R. Repanti, M. Ordi, J. Shipitsyna, E. Kukk, K. Rosenlund, M. Kirschner, B. Powell, N. Ševčík, Libor Colau, B. Holl, K. Rosillon, D. Schledermann, D. Reich, O. Nowakowski, A. M. Savicheva, A. Quint, W. Jenkins, D. Dvořáčková, Jana
n3:wos
000314069400012
s:issn
0020-7136
s:numberOfPages
14
n13:doi
10.1002/ijc.27713