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Statements

Subject Item
n2:RIV%2F00843989%3A_____%2F11%3A00102042%21RIV12-MZ0-00843989
rdf:type
skos:Concept n15:Vysledek
dcterms:description
The authors report a case of a 64-year-old man with chronic lymphocytic leukaemia (CLL) diagnosed 5 years ago. Recently, the patient was admitted with a tumour of the skin in the left lumbar region. Histological and immunohistochemical examinations established the diagnosis of Merkel cell carcinoma (MCC). Electron-microscopic examination revealed the formation of spherical aggregates of intermediate-sized filaments in the perinuclear region. The coincidence of MCC and CLL is rather rare and in published cases, no cytogenetic examinations were performed. We examined the RB1 gene using the interphase FISH method. A biallelic deletion in CLL tumour cells was detected; in MCC tumour cells, biallelic deletion was found in 33 % of the cells and monoallelic deletion in 57 % of the cells. In addition, chromosome 6 trisomy and 1p36 deletion were detected. Examination of non-neoplastic cells of the patient’s skin showed a biallelic presence of the RB1 gene. According to the relevant literature, The authors report a case of a 64-year-old man with chronic lymphocytic leukaemia (CLL) diagnosed 5 years ago. Recently, the patient was admitted with a tumour of the skin in the left lumbar region. Histological and immunohistochemical examinations established the diagnosis of Merkel cell carcinoma (MCC). Electron-microscopic examination revealed the formation of spherical aggregates of intermediate-sized filaments in the perinuclear region. The coincidence of MCC and CLL is rather rare and in published cases, no cytogenetic examinations were performed. We examined the RB1 gene using the interphase FISH method. A biallelic deletion in CLL tumour cells was detected; in MCC tumour cells, biallelic deletion was found in 33 % of the cells and monoallelic deletion in 57 % of the cells. In addition, chromosome 6 trisomy and 1p36 deletion were detected. Examination of non-neoplastic cells of the patient’s skin showed a biallelic presence of the RB1 gene. According to the relevant literature,
dcterms:title
Coincidence of chronic lymphocytic leukaemia with Merkel cell carcinoma: deletion of the RB1 gene in both tumors Coincidence of chronic lymphocytic leukaemia with Merkel cell carcinoma: deletion of the RB1 gene in both tumors
skos:prefLabel
Coincidence of chronic lymphocytic leukaemia with Merkel cell carcinoma: deletion of the RB1 gene in both tumors Coincidence of chronic lymphocytic leukaemia with Merkel cell carcinoma: deletion of the RB1 gene in both tumors
skos:notation
RIV/00843989:_____/11:00102042!RIV12-MZ0-00843989
n15:predkladatel
n17:ico%3A00843989
n4:aktivita
n14:V
n4:aktivity
V
n4:cisloPeriodika
3
n4:dodaniDat
n13:2012
n4:domaciTvurceVysledku
n8:7095066
n4:druhVysledku
n9:J
n4:duvernostUdaju
n16:S
n4:entitaPredkladatele
n6:predkladatel
n4:idSjednocenehoVysledku
190805
n4:idVysledku
RIV/00843989:_____/11:00102042
n4:jazykVysledku
n7:eng
n4:klicovaSlova
Merkel cell carcinoma; chronic lymphocytic leukaemia; immunohistochemistry; RB1 gene
n4:klicoveSlovo
n10:RB1%20gene n10:Merkel%20cell%20carcinoma n10:immunohistochemistry n10:chronic%20lymphocytic%20leukaemia
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[B2F64AB4D620]
n4:nazevZdroje
Česko-slovenská patologie a soudní lékařství
n4:obor
n5:FP
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
4
n4:rokUplatneniVysledku
n13:2011
n4:svazekPeriodika
47/56
n4:tvurceVysledku
Dvořáčková, Jana Uvírová, M. Kuglík, P. Mačák, J.
s:issn
1210-7875
s:numberOfPages
4