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Statements

Subject Item
n2:RIV%2F00843989%3A_____%2F11%3A00102024%21RIV12-MZ0-00843989
rdf:type
n9:Vysledek skos:Concept
dcterms:description
Background: Oncogenous osteomalacia (OOM), which is also known as tumour-induced osteomalacia, is a rare condition associated with a neoplasm and a related systemic bone demineralization caused by renal phosphate wasting. OOM usually occurs in association with a variety of different mesenchymal tumours, and they were categorized into four distinct morphological patterns which they termed %22phosphaturic mesenchymal tumour%22. Of its 4 histopathological subtypes, the mixed connective tissue variant is most commonly observed. Only 10% of cases appear in the head and neck regions and moreover, only 5 previously published tumors were localized in the sinonasal area. The authors describe a case of a man with a PMT originating from the frontoethmoidal region. Case presentation: A 53-year-old man was referred to our ORL clinic due to a presence of a mass at the nasal root having been growing asymptomatically for 1 year. CT scans demonstrated a large (25 x 20 x 35 mm) bilateral frontoethmoidal mass with destruction of nasal bones. The tumor did not appear to invade to the anterior skull base. A selective angiography revealed a moderate hypervascularization of the tumour during early and late arterial phases. The tumour was removed from the external approach and the definitive histopathological diagnosis was a phospaturic mesenchymal tumor. Dual energy X-ray absorptiometry revealed a slight osteopenia of the first and second lumbar vertebrae and neck of the thigh bone. The serum and urinary levels of both calcium and anorganic phosphate were within normal limits. The patient is doing well three years after the operation, and the serum and urine levels of calcium and phosphate remain well within normal limits. Conclusion: PMT is rare in the sinonasal region, it can be rarely observed without the signs of osteomalacia. Background: Oncogenous osteomalacia (OOM), which is also known as tumour-induced osteomalacia, is a rare condition associated with a neoplasm and a related systemic bone demineralization caused by renal phosphate wasting. OOM usually occurs in association with a variety of different mesenchymal tumours, and they were categorized into four distinct morphological patterns which they termed %22phosphaturic mesenchymal tumour%22. Of its 4 histopathological subtypes, the mixed connective tissue variant is most commonly observed. Only 10% of cases appear in the head and neck regions and moreover, only 5 previously published tumors were localized in the sinonasal area. The authors describe a case of a man with a PMT originating from the frontoethmoidal region. Case presentation: A 53-year-old man was referred to our ORL clinic due to a presence of a mass at the nasal root having been growing asymptomatically for 1 year. CT scans demonstrated a large (25 x 20 x 35 mm) bilateral frontoethmoidal mass with destruction of nasal bones. The tumor did not appear to invade to the anterior skull base. A selective angiography revealed a moderate hypervascularization of the tumour during early and late arterial phases. The tumour was removed from the external approach and the definitive histopathological diagnosis was a phospaturic mesenchymal tumor. Dual energy X-ray absorptiometry revealed a slight osteopenia of the first and second lumbar vertebrae and neck of the thigh bone. The serum and urinary levels of both calcium and anorganic phosphate were within normal limits. The patient is doing well three years after the operation, and the serum and urine levels of calcium and phosphate remain well within normal limits. Conclusion: PMT is rare in the sinonasal region, it can be rarely observed without the signs of osteomalacia.
dcterms:title
Phosphaturic mesenchymal tumour of the sinonasal area: case report and review of the literature Phosphaturic mesenchymal tumour of the sinonasal area: case report and review of the literature
skos:prefLabel
Phosphaturic mesenchymal tumour of the sinonasal area: case report and review of the literature Phosphaturic mesenchymal tumour of the sinonasal area: case report and review of the literature
skos:notation
RIV/00843989:_____/11:00102024!RIV12-MZ0-00843989
n9:predkladatel
n14:ico%3A00843989
n3:aktivita
n6:V
n3:aktivity
V
n3:cisloPeriodika
16
n3:dodaniDat
n8:2012
n3:domaciTvurceVysledku
n5:6733980 n5:8333165 n5:5304407
n3:druhVysledku
n18:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
220205
n3:idVysledku
RIV/00843989:_____/11:00102024
n3:jazykVysledku
n15:eng
n3:klicovaSlova
ontogenetic osteomalacia
n3:klicoveSlovo
n13:ontogenetic%20osteomalacia
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[CAB0417988DC]
n3:nazevZdroje
Head & neck oncology
n3:obor
n10:FF
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n8:2011
n3:svazekPeriodika
3
n3:tvurceVysledku
Zeleník, Karol Komínek, Pavel Stárek, I. Geierová, M. Matoušek, Petr
n3:wos
000296444800001
s:issn
1758-3284
s:numberOfPages
4
n17:doi
10.1186/1758-3284-3-16