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Statements

Subject Item
n2:RIV%2F00843989%3A_____%2F10%3AE0103645%21RIV14-MZ0-00843989
rdf:type
n14:Vysledek skos:Concept
dcterms:description
Infection with cytomegalovirus (CMV) is a major cause of morbidity and mortality in immunosuppressed patients, including organ and bone marrow transplant recipients. The majority of CMV disease is caused by reactivation of alatent infection rather that by newly acquired virus. Many techniques have been currently available to aid in the diagnostics of CMV disease. In this report we performed a prospective evaluation of Quantiferon-CMV assay (Cellestis) to determine whether the test is predictive of CMV disease. CD8+ T-cell CMV-specific immunity was assessed in a longitudinal cohort of 14 kidney transplant recipients. According to our data, subjects with higher cellular immune response measured with Quantiferon test had a lower risk of manifestation of CMV infection than subjects with lower responses. Despite the small number of patients and large intra- and interindividual variability of the data in the study, we observed the Quantiferon-CMV assay to be a sensitive specific test to detect a virus-specific T-cell response. We propose that this assay in combination with viral DNA load estimates may prove to be useful to stratify patients at risk of CMV disease. Infection with cytomegalovirus (CMV) is a major cause of morbidity and mortality in immunosuppressed patients, including organ and bone marrow transplant recipients. The majority of CMV disease is caused by reactivation of alatent infection rather that by newly acquired virus. Many techniques have been currently available to aid in the diagnostics of CMV disease. In this report we performed a prospective evaluation of Quantiferon-CMV assay (Cellestis) to determine whether the test is predictive of CMV disease. CD8+ T-cell CMV-specific immunity was assessed in a longitudinal cohort of 14 kidney transplant recipients. According to our data, subjects with higher cellular immune response measured with Quantiferon test had a lower risk of manifestation of CMV infection than subjects with lower responses. Despite the small number of patients and large intra- and interindividual variability of the data in the study, we observed the Quantiferon-CMV assay to be a sensitive specific test to detect a virus-specific T-cell response. We propose that this assay in combination with viral DNA load estimates may prove to be useful to stratify patients at risk of CMV disease.
dcterms:title
Quantiferon-CMV test in prediction of cytomegalovirus infection after kidney transplantation Quantiferon-CMV test in prediction of cytomegalovirus infection after kidney transplantation
skos:prefLabel
Quantiferon-CMV test in prediction of cytomegalovirus infection after kidney transplantation Quantiferon-CMV test in prediction of cytomegalovirus infection after kidney transplantation
skos:notation
RIV/00843989:_____/10:E0103645!RIV14-MZ0-00843989
n3:aktivita
n6:V
n3:aktivity
V
n3:cisloPeriodika
n. 9
n3:dodaniDat
n9:2014
n3:domaciTvurceVysledku
n5:9421912 n5:3867781 n5:4178777 n5:1964283
n3:druhVysledku
n11:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
283611
n3:idVysledku
RIV/00843989:_____/10:E0103645
n3:jazykVysledku
n15:eng
n3:klicovaSlova
T-cell responses; renal transplantation; disease; immunity; reactivation; individuals; serostatus; protection; recipients
n3:klicoveSlovo
n4:protection n4:individuals n4:T-cell%20responses n4:disease n4:serostatus n4:recipients n4:reactivation n4:renal%20transplantation n4:immunity
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[8A4866F60D04]
n3:nazevZdroje
Transplantation proceedings
n3:obor
n13:EC
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
9
n3:rokUplatneniVysledku
n9:2010
n3:svazekPeriodika
42
n3:tvurceVysledku
Mrázek, J. Lochman, I. Lochmanová, A. Maršálková, Petra Martínek, Arnošt Tomášková, H. Brozmanová, Hana Raszka, J. Dědochová, Jarmila
n3:wos
000284969800041
s:issn
0041-1345
s:numberOfPages
4
n10:doi
10.1016/j.transproceed.2010.07.101