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Statements

Subject Item
n2:RIV%2F00843989%3A_____%2F08%3A00014984%21RIV09-MZ0-00843989
rdf:type
skos:Concept n15:Vysledek
dcterms:description
Cílem studie vylo monitorovat změny v hemokoagulačních parametrech u zdravých dobrovolníků po trombotripsy s 1-hodinovým transkraniálním Dopplerovským monitoringem pomocí 2-4MHz sondy. Materiál a metodika: deset zdravých dobrovolníků podstoupilo 1-hodinovou trombotripsy a. cerebri media (ACM), trombotripsy a. radialis (AR) 20-minutové stndardní ultrazvukové vyšetření (SUV) ve 2-týdenních intervalech. Před zahájením, při ukončení trombotripse či SUV a po 24 hodinách bylo hodnoceno počet krevních destiček, aPTT, alfa-2-antiplastin (AP), plasminogen, PAI-1 antigen, euglobulínová fibrinolýzaIEF, homocystein a lipoprotein. Byly sledovány všechny nežádoucí účinky. Výsledky: po trombotripsy ACM došlo k signifikantnímu snížení PAI-1 antigenu, tPA antigenu, fibrinogenu a AP aktivity o 32,23,7, resp. 4%. Po trombotripsu AR došlo ke snížení jen tPA antigenu a to o 14%. Po SUV nedošlo ke změně ve sledovaných parametrech. Závěr: trombotripsw pomocí 1-hodinového TCD monitoringu s 2-4 MHz diagnostick Introduction: The aim of this study was to monitor the changes in haemocoagulation parameters in healthy volunteers after a thrombotripsy with 1-hour transcranial Doppler (TCD) monitoring. Materials and Methods: Ten healthy volunteers (5 males and 5 females; age range, 50 ? 70 years; mean age, 56.1 ? 4.5 years) underwent a 1-hour thrombotripsy of the middle cerebral artery (MCA) using a standard diagnostic transcranial 2 ? 4 MHz probe. Two weeks later the subjects underwent a thrombotripsy of the radial artery, and 4 weeks thereafter a standard 20-minute neurosonologic examination (NSE) was conducted. The following measures of coagulation status were determined before, upon completion, and 24 hours after the thrombotripsy: platelet count, aPTT, prothrombin time, fibrinogen, D-dimers, tPA, FDP, ?-2-antiplasmin (AP), plasminogen, PAI-1 antigen, time of euglobulin clot lysis (ECL), homocysteine, and lipoprotein (a). All adverse events were monitored over a 3 month follow-up period. Result Introduction: The aim of this study was to monitor the changes in haemocoagulation parameters in healthy volunteers after a thrombotripsy with 1-hour transcranial Doppler (TCD) monitoring. Materials and Methods: Ten healthy volunteers (5 males and 5 females; age range, 50 ? 70 years; mean age, 56.1 ? 4.5 years) underwent a 1-hour thrombotripsy of the middle cerebral artery (MCA) using a standard diagnostic transcranial 2 ? 4 MHz probe. Two weeks later the subjects underwent a thrombotripsy of the radial artery, and 4 weeks thereafter a standard 20-minute neurosonologic examination (NSE) was conducted. The following measures of coagulation status were determined before, upon completion, and 24 hours after the thrombotripsy: platelet count, aPTT, prothrombin time, fibrinogen, D-dimers, tPA, FDP, ?-2-antiplasmin (AP), plasminogen, PAI-1 antigen, time of euglobulin clot lysis (ECL), homocysteine, and lipoprotein (a). All adverse events were monitored over a 3 month follow-up period. Result
dcterms:title
Změny v hemokoagulaci u zdravých dobrovolníků po 1-hodoinové trombotripsy pomocí diagnostické 2-4MHz transkraniální sondy Changes in haemocoagulation in healthy volunteers after a 1-hour thrombotripsy using a diagnostic 2-4 MHz transcranial probe Changes in haemocoagulation in healthy volunteers after a 1-hour thrombotripsy using a diagnostic 2-4 MHz transcranial probe
skos:prefLabel
Changes in haemocoagulation in healthy volunteers after a 1-hour thrombotripsy using a diagnostic 2-4 MHz transcranial probe Changes in haemocoagulation in healthy volunteers after a 1-hour thrombotripsy using a diagnostic 2-4 MHz transcranial probe Změny v hemokoagulaci u zdravých dobrovolníků po 1-hodoinové trombotripsy pomocí diagnostické 2-4MHz transkraniální sondy
skos:notation
RIV/00843989:_____/08:00014984!RIV09-MZ0-00843989
n4:aktivita
n16:P
n4:aktivity
P(NR9487)
n4:cisloPeriodika
2
n4:dodaniDat
n10:2009
n4:domaciTvurceVysledku
n6:1669079 n6:2527847 n6:3054691 n6:8004420
n4:druhVysledku
n14:J
n4:duvernostUdaju
n13:S
n4:entitaPredkladatele
n7:predkladatel
n4:idSjednocenehoVysledku
359451
n4:idVysledku
RIV/00843989:_____/08:00014984
n4:jazykVysledku
n17:eng
n4:klicovaSlova
ultrasound monitoring; haemocoagulation; fibrinolytic system; transcranial probe
n4:klicoveSlovo
n5:haemocoagulation n5:ultrasound%20monitoring n5:fibrinolytic%20system n5:transcranial%20probe
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[0790742C8B6D]
n4:nazevZdroje
Journal of thrombosis and thrombolysis
n4:obor
n8:FH
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
11
n4:projekt
n9:NR9487
n4:rokUplatneniVysledku
n10:2008
n4:svazekPeriodika
26
n4:tvurceVysledku
Kaňovský, P. Blatný, J. Školoudík, David Penka, M. Langová, K. Herzig, R. Fadrná, Táňa Zapletal, O. Bar, Michal Hluštík, P. Zapletalová, Olga
n4:wos
000260618500008
s:issn
0929-5305
s:numberOfPages
6