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Statements

Subject Item
n2:RIV%2F00843989%3A_____%2F07%3A00015024%21RIV09-MZ0-00843989
rdf:type
n8:Vysledek skos:Concept
dcterms:description
V publikovaných studiích, týkajících se karcinomu prostaty, se uvádí, že amplifikace genu c-myc je pevně spojena s imunohistochemickou overexpresí proteinu Myc. Existuje předpoklad, že nadměrná exprese proteinu Myc způsobuje degradaci proteinu p27 vedoucí k aktivaci dráhy cyklin E/cyclin-dependentní kinázy 2 a buněčné proliferaci. Jelikož je prokázáno , že s progresí karcinomu prostaty je spojeno mnoho chromozomálních a genetických abnormalit, bylo cílem naší studie prokázat, zda existuje vztah exprese proteinu p27 k těmto genetickým abnormitám.Protože nejčastěji postiženým chromozomem u karcinomu prostaty je chromozom 8 a nejčastějšími chromozomálními změnami jsou delece 8p22 a amplifikace oblasti 8q24, byly hodnoceny právě tyto změny. Naše ýsledky jsou plně v souladu s literárními údaji. Degradace proteinu p27 představovaná expresí 0-25% převládá u skupiny karcinomů s nálezem chromozomálních změn. U karcinomů s amplifikací genu c-myc je nález výrazně snížené exprese proteinu p Published studies on prostate carcinoma report a strong connection between the c-myc gene amplification and immunohistochemical overexpression of the Myc protein.It is assumed that excessive Myc protein expression causes degradation of protein p27 resulting in activationof the pathway of cyclin E/cyclin-dependent kinase 2 and cell proliferation.Since it is known that numerous chromosomal and genetic abnormalities are connected to prostate carcinoma progression, the aim of the study was to show whether anyrelation exists between protein p27 expression and various genetic abnormities. Given that in prostate carcinoma, chromosome 8 is most usually affected, deletions 8p22and amplifications of zone 8q24 being the most frequent chromosomal changes, these were the most appropriate ones for evaluation. Our findings are in complete accord with the literature. Degradation of protein p27 represented by expression in 0-25 % prevailed in a group of prostate cancers with a finding of chromosomal ch Published studies on prostate carcinoma report a strong connection between the c-myc gene amplification and immunohistochemical overexpression of the Myc protein.It is assumed that excessive Myc protein expression causes degradation of protein p27 resulting in activationof the pathway of cyclin E/cyclin-dependent kinase 2 and cell proliferation.Since it is known that numerous chromosomal and genetic abnormalities are connected to prostate carcinoma progression, the aim of the study was to show whether anyrelation exists between protein p27 expression and various genetic abnormities. Given that in prostate carcinoma, chromosome 8 is most usually affected, deletions 8p22and amplifications of zone 8q24 being the most frequent chromosomal changes, these were the most appropriate ones for evaluation. Our findings are in complete accord with the literature. Degradation of protein p27 represented by expression in 0-25 % prevailed in a group of prostate cancers with a finding of chromosomal ch
dcterms:title
<A >Molecularly Genetic Determination of Prognostic Factors of the Prostate Cancer and Their Relationships to Expression of Protein p27kip1 Vztah exprese p27kip1 k výskytu genetických abnormit u negeneralizovaného karcinomu prostaty <A >Molecularly Genetic Determination of Prognostic Factors of the Prostate Cancer and Their Relationships to Expression of Protein p27kip1
skos:prefLabel
<A >Molecularly Genetic Determination of Prognostic Factors of the Prostate Cancer and Their Relationships to Expression of Protein p27kip1 Vztah exprese p27kip1 k výskytu genetických abnormit u negeneralizovaného karcinomu prostaty <A >Molecularly Genetic Determination of Prognostic Factors of the Prostate Cancer and Their Relationships to Expression of Protein p27kip1
skos:notation
RIV/00843989:_____/07:00015024!RIV09-MZ0-00843989
n3:aktivita
n7:V
n3:aktivity
V
n3:cisloPeriodika
2
n3:dodaniDat
n15:2009
n3:domaciTvurceVysledku
n11:7095066
n3:druhVysledku
n16:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
407958
n3:idVysledku
RIV/00843989:_____/07:00015024
n3:jazykVysledku
n14:eng
n3:klicovaSlova
8p22 loss; 8q24 amplification; prostate cancer; Gleason´s score; p27Kipl; prognosis
n3:klicoveSlovo
n4:prognosis n4:Gleason%C2%B4s%20score n4:8q24%20amplification n4:8p22%20loss n4:prostate%20cancer n4:p27Kipl
n3:kodStatuVydavatele
SK - Slovenská republika
n3:kontrolniKodProRIV
[8DCE278D2C0D]
n3:nazevZdroje
Neoplasma
n3:obor
n13:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
2
n3:rokUplatneniVysledku
n15:2007
n3:svazekPeriodika
54
n3:tvurceVysledku
Dvořáčková, Jana Uvírová, M.
n3:wos
000246073300010
s:issn
0028-2685
s:numberOfPages
6