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Statements

Subject Item
n2:RIV%2F00843989%3A_____%2F05%3A00100007%21RIV09-MZ0-00843989
rdf:type
n11:Vysledek skos:Concept
dcterms:description
Monocyte chemoattractant protein (MCP)-1 is the key chemokine in the process of atheroslerotic vascular inflammation. Examining already reported association between coronary artery disease (CAD) and the SNP A/G in the MCP-1 gene (position -2518), 139 Czech patients with CAD manifested as myocardial infarction (MI) and 359 unrelated healthy control (C) subjects were genotyped by PCR-SSP. Genotype and allele frequencies were not different in MI and C groups (allele G: MI, 20.5%; C, 23.8%, OR = 0.8, P > 0.05). No differences were detected when the patients were subdivided based on sex or the age of MI first occurrence. Further, no relationship was observed between circulating MCP-1 levels and carriage of the G allele. The data do not support a role for the MCP-1 -2518 single nucleotide polymorphism in susceptibility to CAD manifested by myocardial infarction Monocyte chemoattractant protein (MCP)-1 is the key chemokine in the process of atheroslerotic vascular inflammation. Examining already reported association between coronary artery disease (CAD) and the SNP A/G in the MCP-1 gene (position -2518), 139 Czech patients with CAD manifested as myocardial infarction (MI) and 359 unrelated healthy control (C) subjects were genotyped by PCR-SSP. Genotype and allele frequencies were not different in MI and C groups (allele G: MI, 20.5%; C, 23.8%, OR = 0.8, P > 0.05). No differences were detected when the patients were subdivided based on sex or the age of MI first occurrence. Further, no relationship was observed between circulating MCP-1 levels and carriage of the G allele. The data do not support a role for the MCP-1 -2518 single nucleotide polymorphism in susceptibility to CAD manifested by myocardial infarction Protein MCP-1 je klíčovým chemokinem v procesu aterosklerotického zánětu. Studie ukazuje na vztah mezi kardiovaskulárním onemocněním a SNP A/G polymorfismem v genu
dcterms:title
V české populaci není polymorfismus MCP-1-2518 (A/G) asociován s infarktem myokardu The MCP-1-2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population The MCP-1-2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population
skos:prefLabel
V české populaci není polymorfismus MCP-1-2518 (A/G) asociován s infarktem myokardu The MCP-1-2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population The MCP-1-2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population
skos:notation
RIV/00843989:_____/05:00100007!RIV09-MZ0-00843989
n4:aktivita
n17:P
n4:aktivity
P(NI7308)
n4:cisloPeriodika
5
n4:dodaniDat
n5:2009
n4:domaciTvurceVysledku
n15:2592185
n4:druhVysledku
n8:J
n4:duvernostUdaju
n10:S
n4:entitaPredkladatele
n14:predkladatel
n4:idSjednocenehoVysledku
529147
n4:idVysledku
RIV/00843989:_____/05:00100007
n4:jazykVysledku
n16:eng
n4:klicovaSlova
coronary-artery-disease; chemoattractant protein-1; gene; genotype
n4:klicoveSlovo
n12:gene n12:genotype n12:chemoattractant%20protein-1 n12:coronary-artery-disease
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[986E10DD9D64]
n4:nazevZdroje
International Journal of Immunogenetics
n4:obor
n6:EC
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
7
n4:projekt
n13:NI7308
n4:rokUplatneniVysledku
n5:2005
n4:svazekPeriodika
32
n4:tvurceVysledku
Čermáková, Zuzana
n4:wos
000231902900008
s:issn
1744-3121
s:numberOfPages
4