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Statements

Subject Item
n2:RIV%2F00669806%3A_____%2F13%3A10134276%21RIV14-MZ0-00669806
rdf:type
n4:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1016/j.humpath.2012.04.006
dcterms:description
Juxtaglomerular cell tumors (JGCTs) are rare tumors characterized by renin synthesis, hyperaldosteronism and hypertension. A curious immunohistochemical overlap between JGCT and gastrointestinal stromal tumor (GIST) including the expression of vimentin, CD34, CD 117, alpha-smooth muscle actin was previously reported, prompting us to further investigate JGCT and its phenotypic and molecular genetic characteristics. Virtual karyotyping showed gain of chromosomes 3, 4, 10, 13, 17 and 18 in one JGCT, and fluorescence in situ hybridization (FISH) study confirmed this multiple gain pattern. Additionally, loss of chromosome 9 was observed in four of six cases analyzed with FISH. A whole genome expression analysis revealed 415 up-regulated (including renin, and CD117) and 325 down-regulated genes between the 2 cases. The study confirmed earlier reports on the gain of chromosomes 4 and 10, and provided further evidence of up-regulation of the genes located on these 2 chromosomes. For the first time our study indicated the importance of the loss of chromosome 9 and loss of expression of several tumor suppressor genes located on this chromosome as possible pathogenetic events important in development of JGCT. (C) 2013 Elsevier Inc. All rights reserved. Juxtaglomerular cell tumors (JGCTs) are rare tumors characterized by renin synthesis, hyperaldosteronism and hypertension. A curious immunohistochemical overlap between JGCT and gastrointestinal stromal tumor (GIST) including the expression of vimentin, CD34, CD 117, alpha-smooth muscle actin was previously reported, prompting us to further investigate JGCT and its phenotypic and molecular genetic characteristics. Virtual karyotyping showed gain of chromosomes 3, 4, 10, 13, 17 and 18 in one JGCT, and fluorescence in situ hybridization (FISH) study confirmed this multiple gain pattern. Additionally, loss of chromosome 9 was observed in four of six cases analyzed with FISH. A whole genome expression analysis revealed 415 up-regulated (including renin, and CD117) and 325 down-regulated genes between the 2 cases. The study confirmed earlier reports on the gain of chromosomes 4 and 10, and provided further evidence of up-regulation of the genes located on these 2 chromosomes. For the first time our study indicated the importance of the loss of chromosome 9 and loss of expression of several tumor suppressor genes located on this chromosome as possible pathogenetic events important in development of JGCT. (C) 2013 Elsevier Inc. All rights reserved.
dcterms:title
Juxtaglomerular cell tumor: A morphological, immunohistochemical and genetic study of six cases Juxtaglomerular cell tumor: A morphological, immunohistochemical and genetic study of six cases
skos:prefLabel
Juxtaglomerular cell tumor: A morphological, immunohistochemical and genetic study of six cases Juxtaglomerular cell tumor: A morphological, immunohistochemical and genetic study of six cases
skos:notation
RIV/00669806:_____/13:10134276!RIV14-MZ0-00669806
n4:predkladatel
n17:ico%3A00669806
n3:aktivita
n5:P n5:I
n3:aktivity
I, P(NT12010)
n3:cisloPeriodika
1
n3:dodaniDat
n13:2014
n3:domaciTvurceVysledku
n9:7629990 n9:7709471 n9:3182975 n9:9342710
n3:druhVysledku
n7:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
82051
n3:idVysledku
RIV/00669806:_____/13:10134276
n3:jazykVysledku
n15:eng
n3:klicovaSlova
Whole genome expression array; Fluorescence in situ hybridization; Virtual karyotyping; Juxtaglomerular cell tumor
n3:klicoveSlovo
n8:Virtual%20karyotyping n8:Whole%20genome%20expression%20array n8:Fluorescence%20in%20situ%20hybridization n8:Juxtaglomerular%20cell%20tumor
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[50CD6441FA64]
n3:nazevZdroje
Human Pathology
n3:obor
n11:FP
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
15
n3:projekt
n14:NT12010
n3:rokUplatneniVysledku
n13:2013
n3:svazekPeriodika
44
n3:tvurceVysledku
Michal, Michal Ovcak, Zdenka Ghazalpour, Anatole Bender, Ryan P. Hora, Milan Maris, Sperga Grossmann, Petr Hes, Ondřej Gatalica, Zoran Svajdler, Marian Petersson, Fredrik B. Tan, Puay Hoon Kuroda, Naoto Monzon, Federico A. Thomas, Anjula
n3:wos
000312504400005
s:issn
0046-8177
s:numberOfPages
8
n16:doi
10.1016/j.humpath.2012.04.006