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Statements

Subject Item
n2:RIV%2F00669806%3A_____%2F12%3A10135328%21RIV14-MZ0-00669806
rdf:type
n4:Vysledek skos:Concept
rdfs:seeAlso
http://www.nature.com/bmt/journal/v47/n6/pdf/bmt2011173a.pdf
dcterms:description
G-CSF filgrastim is frequently used to mobilise CD34þ cells in donors before PBSC collection. Several observational reports raised concerns regarding an elevated risk of haematological malignancies after G-CSF administration. It was found that treatment with G-CSF of PBSC donors induced chromosomal tetraploidy in a small subset of mature myeloid cells in the blood,1 epigenetic and genetic alterations in lymphocytes2 and aneuploidy.3 In 2006, Bennett et al.4 reported two cases of AML identified in the sibling donors, whose recipients also suffered with AML, among 200 individuals who had received filgrastim before collection of PBSC for allogeneic transplantation. In a large retrospective EBMT analysis, Halter et al.5 observed 20 haematological malignancies (3.92/10 000), of which 12 were after donating PBSC; however, the observed incidence rate did not exceed the expected incidence in an age- and sex-adjusted general population, and there was no relationship with the type of haematological malignancy in the recipients and donors donating for siblings. We decided to conduct an analysis of follow-up policy and aematological malignancy incidence in related sibling donors of allogeneic PBSC mobilised with G-CSF filgrastim in the period of 2001-2010 at our transplant centre (TC), and to compare the results with those of unrelated donors of the Czech National Marrow Donor Registry (CNMDR). G-CSF filgrastim is frequently used to mobilise CD34þ cells in donors before PBSC collection. Several observational reports raised concerns regarding an elevated risk of haematological malignancies after G-CSF administration. It was found that treatment with G-CSF of PBSC donors induced chromosomal tetraploidy in a small subset of mature myeloid cells in the blood,1 epigenetic and genetic alterations in lymphocytes2 and aneuploidy.3 In 2006, Bennett et al.4 reported two cases of AML identified in the sibling donors, whose recipients also suffered with AML, among 200 individuals who had received filgrastim before collection of PBSC for allogeneic transplantation. In a large retrospective EBMT analysis, Halter et al.5 observed 20 haematological malignancies (3.92/10 000), of which 12 were after donating PBSC; however, the observed incidence rate did not exceed the expected incidence in an age- and sex-adjusted general population, and there was no relationship with the type of haematological malignancy in the recipients and donors donating for siblings. We decided to conduct an analysis of follow-up policy and aematological malignancy incidence in related sibling donors of allogeneic PBSC mobilised with G-CSF filgrastim in the period of 2001-2010 at our transplant centre (TC), and to compare the results with those of unrelated donors of the Czech National Marrow Donor Registry (CNMDR).
dcterms:title
Haematological malignancies in sibling and unrelated donors of allogeneic peripheral stem cells mobilised with G-CSF filgrastim: a transplant centre and Czech National Marrow Donors Registry experience Haematological malignancies in sibling and unrelated donors of allogeneic peripheral stem cells mobilised with G-CSF filgrastim: a transplant centre and Czech National Marrow Donors Registry experience
skos:prefLabel
Haematological malignancies in sibling and unrelated donors of allogeneic peripheral stem cells mobilised with G-CSF filgrastim: a transplant centre and Czech National Marrow Donors Registry experience Haematological malignancies in sibling and unrelated donors of allogeneic peripheral stem cells mobilised with G-CSF filgrastim: a transplant centre and Czech National Marrow Donors Registry experience
skos:notation
RIV/00669806:_____/12:10135328!RIV14-MZ0-00669806
n4:predkladatel
n17:ico%3A00669806
n5:aktivita
n12:I
n5:aktivity
I
n5:cisloPeriodika
6
n5:dodaniDat
n7:2014
n5:domaciTvurceVysledku
n8:2591359 n8:4863712 n8:3069656 n8:1203037 n8:9218955 n8:1204742 n8:6662986 n8:5286158
n5:druhVysledku
n11:J
n5:duvernostUdaju
n10:S
n5:entitaPredkladatele
n14:predkladatel
n5:idSjednocenehoVysledku
138576
n5:idVysledku
RIV/00669806:_____/12:10135328
n5:jazykVysledku
n15:eng
n5:klicovaSlova
events; leukemia; Lymphoma
n5:klicoveSlovo
n9:Lymphoma n9:leukemia n9:events
n5:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n5:kontrolniKodProRIV
[4522540AC650]
n5:nazevZdroje
Bone Marrow Transplantation
n5:obor
n16:FD
n5:pocetDomacichTvurcuVysledku
8
n5:pocetTvurcuVysledku
8
n5:rokUplatneniVysledku
n7:2012
n5:svazekPeriodika
47
n5:tvurceVysledku
Jungová, Alexandra Navrátilová, Jana Výrutová, Radmila Steinerová, Kateřina Svoboda, Tomáš Koza, Vladimír Jindra, Pavel Vokurka, Samuel
n5:wos
000305276200016
s:issn
0268-3369
s:numberOfPages
2
n19:doi
10.1038/bmt.2011.173