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Statements

Subject Item
n2:RIV%2F00669806%3A_____%2F11%3A10105755%21RIV12-MZ0-00669806
rdf:type
skos:Concept n7:Vysledek
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/S1092913410001437
dcterms:description
Mucinous tubular and spindle cell carcinoma (MTSCC) has recently been integrated into the World Health Organization classification. Although MTSCC is generally a low-grade carcinoma, MTSCC with high-grade morphology has been recently reported. We present the first case of high-grade MTSCC with comparative genomic hybridization findings. A 60-year-old Japanese man presented with weight loss and general fatigue. He underwent radical nephrectomy because of the clinical diagnosis of renal cancer. Histologic examination of renal tumor showed findings of high-grade MTSCC. Comparative genomic hybridization analysis showed gain of chromosomes 1q, 7, 16, 19q, and Y and loss of chromosomes 1p, 6p, 8p, 11q (del(11)(q23)), and 13. G-band karyotype showed gain of chromosomes 2, 3, 5, 7, 12, 16, and 20 and loss of chromosome 15. Results of our molecular genetic analysis support the idea that high-grade MTSCC is a real counterpart of low-grade MTSCC. There is no evidence to designate such tumors as unclassified renal cell carcinoma. Mucinous tubular and spindle cell carcinoma (MTSCC) has recently been integrated into the World Health Organization classification. Although MTSCC is generally a low-grade carcinoma, MTSCC with high-grade morphology has been recently reported. We present the first case of high-grade MTSCC with comparative genomic hybridization findings. A 60-year-old Japanese man presented with weight loss and general fatigue. He underwent radical nephrectomy because of the clinical diagnosis of renal cancer. Histologic examination of renal tumor showed findings of high-grade MTSCC. Comparative genomic hybridization analysis showed gain of chromosomes 1q, 7, 16, 19q, and Y and loss of chromosomes 1p, 6p, 8p, 11q (del(11)(q23)), and 13. G-band karyotype showed gain of chromosomes 2, 3, 5, 7, 12, 16, and 20 and loss of chromosome 15. Results of our molecular genetic analysis support the idea that high-grade MTSCC is a real counterpart of low-grade MTSCC. There is no evidence to designate such tumors as unclassified renal cell carcinoma.
dcterms:title
High-grade mucinous tubular and spindle cell carcinoma: comparative genomic hybridization study High-grade mucinous tubular and spindle cell carcinoma: comparative genomic hybridization study
skos:prefLabel
High-grade mucinous tubular and spindle cell carcinoma: comparative genomic hybridization study High-grade mucinous tubular and spindle cell carcinoma: comparative genomic hybridization study
skos:notation
RIV/00669806:_____/11:10105755!RIV12-MZ0-00669806
n7:predkladatel
n8:ico%3A00669806
n3:aktivita
n13:V
n3:aktivity
V
n3:cisloPeriodika
6
n3:dodaniDat
n16:2012
n3:domaciTvurceVysledku
n11:7629990 n11:9342710
n3:druhVysledku
n5:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
202068
n3:idVysledku
RIV/00669806:_____/11:10105755
n3:jazykVysledku
n19:eng
n3:klicovaSlova
Comparative genomic hybridization; High grade; Mucinous tubular and spindle cell carcinoma; Kidney
n3:klicoveSlovo
n9:High%20grade n9:Mucinous%20tubular%20and%20spindle%20cell%20carcinoma n9:Kidney n9:Comparative%20genomic%20hybridization
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[76E9A0A19462]
n3:nazevZdroje
Annals of Diagnostic Pathology
n3:obor
n6:FP
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
10
n3:rokUplatneniVysledku
n16:2011
n3:svazekPeriodika
15
n3:tvurceVysledku
Hes, Ondřej Taguchi, Takahiro Lee, Gang-Hong Michal, Michal Shuin, Taro Inoue, Keiji Tamura, Masato Naroda, Takushi Tominaga, Akira Kuroda, Naoto
n3:wos
000297481900018
s:issn
1092-9134
s:numberOfPages
4
n18:doi
10.1016/j.anndiagpath.2010.08.003