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Statements

Subject Item
n2:RIV%2F00216305%3A26620%2F14%3APU111500%21RIV15-MSM-26620___
rdf:type
n11:Vysledek skos:Concept
dcterms:description
The present paper describes the synthesis, characterization, and utilization of multi-functional magnetic conjugates that integrate optical and magnetic properties in a single structure for use in many biomedical applications. Spontaneous interaction with eukaryotic cell membrane (HEK-239 cell culture) was determined using fluorescence microscopy, and fluorescence analyses. Both, differences in excitation, and emission wavelength were observed, caused by glutathione intake by cells, resulting in disintegration of core–shell structure of quantum dots, as well as adhesion of conjugate onto cell surface. When compared with quantum dots fluorescent properties, HEK-239 cells with incorporated nanoconjugate exhibited two excitation maxima (ex = 430 and 390 nm). Simultaneously, application of ideal ex for quantum dots (ex = 430 nm), resulted in two emission maxima ( = 740 and 750 nm). This nanoconjugate fulfills the requirements of term theranostics, because it can be further functionalized with biomolecul The present paper describes the synthesis, characterization, and utilization of multi-functional magnetic conjugates that integrate optical and magnetic properties in a single structure for use in many biomedical applications. Spontaneous interaction with eukaryotic cell membrane (HEK-239 cell culture) was determined using fluorescence microscopy, and fluorescence analyses. Both, differences in excitation, and emission wavelength were observed, caused by glutathione intake by cells, resulting in disintegration of core–shell structure of quantum dots, as well as adhesion of conjugate onto cell surface. When compared with quantum dots fluorescent properties, HEK-239 cells with incorporated nanoconjugate exhibited two excitation maxima (ex = 430 and 390 nm). Simultaneously, application of ideal ex for quantum dots (ex = 430 nm), resulted in two emission maxima ( = 740 and 750 nm). This nanoconjugate fulfills the requirements of term theranostics, because it can be further functionalized with biomolecul
dcterms:title
y-Fe2O3 Nanoparticles Covered with Glutathione-Modified Quantum Dots as a Fluorescent Nanotransporter y-Fe2O3 Nanoparticles Covered with Glutathione-Modified Quantum Dots as a Fluorescent Nanotransporter
skos:prefLabel
y-Fe2O3 Nanoparticles Covered with Glutathione-Modified Quantum Dots as a Fluorescent Nanotransporter y-Fe2O3 Nanoparticles Covered with Glutathione-Modified Quantum Dots as a Fluorescent Nanotransporter
skos:notation
RIV/00216305:26620/14:PU111500!RIV15-MSM-26620___
n3:aktivita
n6:P
n3:aktivity
P(ED1.1.00/02.0068)
n3:cisloPeriodika
21-22
n3:dodaniDat
n4:2015
n3:domaciTvurceVysledku
n7:6359914 n7:9584366 n7:8740658 n7:3931315 n7:4995775 n7:2307049
n3:druhVysledku
n10:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
56495
n3:idVysledku
RIV/00216305:26620/14:PU111500
n3:jazykVysledku
n9:eng
n3:klicovaSlova
Excitation, HEK-239, Luminescence, Nanoconjugate, Theranostics
n3:klicoveSlovo
n8:Luminescence n8:Excitation n8:HEK-239 n8:Theranostics n8:Nanoconjugate
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[E10725AC63E5]
n3:nazevZdroje
CHROMATOGRAPHIA
n3:obor
n14:CG
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
8
n3:projekt
n17:ED1.1.00%2F02.0068
n3:rokUplatneniVysledku
n4:2014
n3:svazekPeriodika
77
n3:tvurceVysledku
Blažková, Iva Zítka, Ondřej Masařík, Michal Cernei, Natalia Vladimirovna Kopel, Pavel Adam, Vojtěch Kizek, René Heger, Zbyněk
s:issn
0009-5893
s:numberOfPages
8
n13:organizacniJednotka
26620