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Statements

Subject Item
n2:RIV%2F00216305%3A26620%2F14%3APU111498%21RIV15-MSM-26620___
rdf:type
skos:Concept n12:Vysledek
dcterms:description
Ellipticine (5,11-dimethyl-6H-pyrido[4,3-b]carbazole) is an alkaloid that has been isolated from plants of an Apocynaceae family. It is one of the simplest naturally occurring alkaloids with a planar structure. Over the past decades, ellipticine became a very promising antitumor agent. Interaction with DNA is one of the most studied ellipticine effects on cell division. This phenomenon is not clearly explained so far. In our experiments we studied interaction of ellipticine with single-stranded and double-stranded oligonucleotides by electrochemical methods on mercury electrode. Differential pulse voltammetry was applied for ellipticine (Elli) and CA peak detection. Square wave voltammetry was applied for G peak detection. The effect of the interaction time and ellipticine concentrations on interactions of ellipticine with single- and double-stranded oligonucleotides was tested too. Ellipticine (5,11-dimethyl-6H-pyrido[4,3-b]carbazole) is an alkaloid that has been isolated from plants of an Apocynaceae family. It is one of the simplest naturally occurring alkaloids with a planar structure. Over the past decades, ellipticine became a very promising antitumor agent. Interaction with DNA is one of the most studied ellipticine effects on cell division. This phenomenon is not clearly explained so far. In our experiments we studied interaction of ellipticine with single-stranded and double-stranded oligonucleotides by electrochemical methods on mercury electrode. Differential pulse voltammetry was applied for ellipticine (Elli) and CA peak detection. Square wave voltammetry was applied for G peak detection. The effect of the interaction time and ellipticine concentrations on interactions of ellipticine with single- and double-stranded oligonucleotides was tested too.
dcterms:title
Electrochemical Study of Ellipticine Interaction with Single and Double Stranded Oligonucleotides Electrochemical Study of Ellipticine Interaction with Single and Double Stranded Oligonucleotides
skos:prefLabel
Electrochemical Study of Ellipticine Interaction with Single and Double Stranded Oligonucleotides Electrochemical Study of Ellipticine Interaction with Single and Double Stranded Oligonucleotides
skos:notation
RIV/00216305:26620/14:PU111498!RIV15-MSM-26620___
n4:aktivita
n13:P n13:I
n4:aktivity
I, P(ED1.1.00/02.0068), P(GAP301/10/0356)
n4:cisloPeriodika
2
n4:dodaniDat
n15:2015
n4:domaciTvurceVysledku
n11:8184208 n11:8541698 n11:2307049 n11:6044786 n11:9600426 n11:3790185 n11:4995775
n4:druhVysledku
n14:J
n4:duvernostUdaju
n17:S
n4:entitaPredkladatele
n18:predkladatel
n4:idSjednocenehoVysledku
14119
n4:idVysledku
RIV/00216305:26620/14:PU111498
n4:jazykVysledku
n7:eng
n4:klicovaSlova
Adsorptive transfer stripping technique, DNA, differential pulse voltammetry, ellipticine, hetero-nucleotides, intercalation, square wave voltammetry, cancer, therapy
n4:klicoveSlovo
n9:ellipticine n9:Adsorptive%20transfer%20stripping%20technique n9:hetero-nucleotides n9:cancer n9:square%20wave%20voltammetry n9:differential%20pulse%20voltammetry n9:therapy n9:DNA n9:intercalation
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[628D7C17DE66]
n4:nazevZdroje
Anti-Cancer Agents in Medicinal Chemistry
n4:obor
n8:CG
n4:pocetDomacichTvurcuVysledku
7
n4:pocetTvurcuVysledku
9
n4:projekt
n6:ED1.1.00%2F02.0068 n6:GAP301%2F10%2F0356
n4:rokUplatneniVysledku
n15:2014
n4:svazekPeriodika
14
n4:tvurceVysledku
Babula, Petr Eckschlager, Tomáš Adam, Vojtěch Kizek, René Stiborová, Marie Krejčová, Ludmila Trnková, Libuše Hynek, David Tmejová, Kateřina
n4:wos
000331462800016
s:issn
1871-5206
s:numberOfPages
10
n16:organizacniJednotka
26620