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Statements

Subject Item
n2:RIV%2F00216305%3A26620%2F14%3APU109895%21RIV15-MSM-26620___
rdf:type
skos:Concept n7:Vysledek
dcterms:description
Carbon nanomaterials, including fullerenes, exhibit not only unique structure and electronic properties but also a significant potential to serve as radical scavengers and/or anti-oxidants. Their conjugation with anticancer drugs such as doxorubicin (DOX) may help to balance severe negative side effects of these cytostatics and also improve the delivery of the drug taking advantage of the enhanced cellular uptake, selectivity to cancer cells, and pH regulated release. In this study, the fullerene (C60) surface was oxidized by concentrated nitric acid, which enabled simple DOX–fullerene conjugation based on stacking and hydrophilic interactions with carboxylic groups. The strength of this noncovalent binding is pH dependent. At a low pH, the amino group of DOX is protonated, however at a higher pH, the amino group is deprotonated, resulting in stronger hydrophobic interactions with the fullerene walls. CE and HPLC were employed for characterization of resulting complexes. The cell toxicity of the con Carbon nanomaterials, including fullerenes, exhibit not only unique structure and electronic properties but also a significant potential to serve as radical scavengers and/or anti-oxidants. Their conjugation with anticancer drugs such as doxorubicin (DOX) may help to balance severe negative side effects of these cytostatics and also improve the delivery of the drug taking advantage of the enhanced cellular uptake, selectivity to cancer cells, and pH regulated release. In this study, the fullerene (C60) surface was oxidized by concentrated nitric acid, which enabled simple DOX–fullerene conjugation based on stacking and hydrophilic interactions with carboxylic groups. The strength of this noncovalent binding is pH dependent. At a low pH, the amino group of DOX is protonated, however at a higher pH, the amino group is deprotonated, resulting in stronger hydrophobic interactions with the fullerene walls. CE and HPLC were employed for characterization of resulting complexes. The cell toxicity of the con
dcterms:title
Fullerene as a transporter for doxorubicin investigated by analytical methods and in vivo imaging Fullerene as a transporter for doxorubicin investigated by analytical methods and in vivo imaging
skos:prefLabel
Fullerene as a transporter for doxorubicin investigated by analytical methods and in vivo imaging Fullerene as a transporter for doxorubicin investigated by analytical methods and in vivo imaging
skos:notation
RIV/00216305:26620/14:PU109895!RIV15-MSM-26620___
n3:aktivita
n15:O n15:P
n3:aktivity
O, P(ED1.1.00/02.0068)
n3:cisloPeriodika
7
n3:dodaniDat
n12:2015
n3:domaciTvurceVysledku
n8:6359914 n8:8541698 n8:3955397 n8:7957092 n8:7954735 Nguyen, Hoai Viet n8:8184208 n8:4995775 n8:8740658
n3:druhVysledku
n16:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
17624
n3:idVysledku
RIV/00216305:26620/14:PU109895
n3:jazykVysledku
n18:eng
n3:klicovaSlova
Clinical analysis, Doxorubicin, Drug delivery, Embryo, Fullerene, Nanomedicine
n3:klicoveSlovo
n6:Nanomedicine n6:Doxorubicin n6:Clinical%20analysis n6:Fullerene n6:Drug%20delivery n6:Embryo
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[0F1F84635959]
n3:nazevZdroje
Electrophoresis
n3:obor
n14:CG
n3:pocetDomacichTvurcuVysledku
9
n3:pocetTvurcuVysledku
12
n3:projekt
n11:ED1.1.00%2F02.0068
n3:rokUplatneniVysledku
n12:2014
n3:svazekPeriodika
35
n3:tvurceVysledku
Beklová, Miroslava Nguyen, Hoai Viet Hynek, David Konečná, Romana Chudobová, Dagmar Kizek, René Blažková, Iva Kopel, Pavel Adam, Vojtěch Krejčová, Ludmila Komínková, Markéta Zítka, Ondřej
s:issn
0173-0835
s:numberOfPages
10
n4:organizacniJednotka
26620