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Statements

Subject Item
n2:RIV%2F00216305%3A26620%2F12%3APU99117%21RIV13-AV0-26620___
rdf:type
n9:Vysledek skos:Concept
dcterms:description
Prion diseases are fatal neurodegenerative and infectious disorders of humans and animals, characterized by structural transition of the host-encoded cellular prion protein (PrPC) into the aberrantly folded pathologic isoform PrPSc. The conformation change, from the a-helix in the natural protein form (PrPc) to the b-sheet of the modified protein form (PrPSc), significantly influence the protein function. The mutated form (PrPSc) is extremely resistant to the cell degradation processes and may bind other PrPc molecules inducing the conformation change to the PrPSc. The insufficiency of the physiological PrPc and toxic incidence of PrPSc participate on the genesis of prion neurodegenerative diseases. The main aim of this study was to suggest electrochemical methods for detection of b-sheet breaker prion protein. For this purpose cyclic voltammetry (CV), differential pulse voltammetry (DPV), differential pulse voltammetry Brdicka reaction and chronopotentiometric stripping analysis (CPSA) were used. Pri Prion diseases are fatal neurodegenerative and infectious disorders of humans and animals, characterized by structural transition of the host-encoded cellular prion protein (PrPC) into the aberrantly folded pathologic isoform PrPSc. The conformation change, from the a-helix in the natural protein form (PrPc) to the b-sheet of the modified protein form (PrPSc), significantly influence the protein function. The mutated form (PrPSc) is extremely resistant to the cell degradation processes and may bind other PrPc molecules inducing the conformation change to the PrPSc. The insufficiency of the physiological PrPc and toxic incidence of PrPSc participate on the genesis of prion neurodegenerative diseases. The main aim of this study was to suggest electrochemical methods for detection of b-sheet breaker prion protein. For this purpose cyclic voltammetry (CV), differential pulse voltammetry (DPV), differential pulse voltammetry Brdicka reaction and chronopotentiometric stripping analysis (CPSA) were used. Pri
dcterms:title
Electrochemical Behaviour of Native and Denatured B-Sheet Breaker Prion Protein Electrochemical Behaviour of Native and Denatured B-Sheet Breaker Prion Protein
skos:prefLabel
Electrochemical Behaviour of Native and Denatured B-Sheet Breaker Prion Protein Electrochemical Behaviour of Native and Denatured B-Sheet Breaker Prion Protein
skos:notation
RIV/00216305:26620/12:PU99117!RIV13-AV0-26620___
n9:predkladatel
n15:orjk%3A26620
n3:aktivita
n6:P
n3:aktivity
P(ED1.1.00/02.0068), P(GAP102/11/1068), P(IAA401990701), P(KAN208130801)
n3:cisloPeriodika
2
n3:dodaniDat
n16:2013
n3:domaciTvurceVysledku
n4:7333323 n4:8541698 n4:4489705 n4:2032279 n4:4995775 n4:2307049
n3:druhVysledku
n18:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
133855
n3:idVysledku
RIV/00216305:26620/12:PU99117
n3:jazykVysledku
n8:eng
n3:klicovaSlova
Prion protein (PrPSc – scrapie), Adsorptive transfer stripping technique, cyclic voltammetry (CV), differential pulse voltammetry (DPV), Brdicka reaction, Chronopotenciometric stripping analysis (CPSA)
n3:klicoveSlovo
n7:Prion%20protein%20%28PrPSc%20%E2%80%93%20scrapie%29 n7:Brdicka%20reaction n7:differential%20pulse%20voltammetry%20%28DPV%29 n7:Chronopotenciometric%20stripping%20analysis%20%28CPSA%29 n7:Adsorptive%20transfer%20stripping%20technique n7:cyclic%20voltammetry%20%28CV%29
n3:kodStatuVydavatele
RS - Srbská republika
n3:kontrolniKodProRIV
[BC0052F4FF82]
n3:nazevZdroje
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
n3:obor
n12:CG
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
6
n3:projekt
n10:GAP102%2F11%2F1068 n10:ED1.1.00%2F02.0068 n10:KAN208130801 n10:IAA401990701
n3:rokUplatneniVysledku
n16:2012
n3:svazekPeriodika
7
n3:tvurceVysledku
Šobrová, Pavlína Hynek, David Adam, Vojtěch Vaculovičová, Markéta Hubálek, Jaromír Kizek, René
n3:wos
000302730000003
s:issn
1452-3981
s:numberOfPages
15
n19:organizacniJednotka
26620