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Statements

Subject Item
n2:RIV%2F00216305%3A26310%2F13%3APU105842%21RIV14-MSM-26310___
rdf:type
n9:Vysledek skos:Concept
dcterms:description
The biocompatibility and biodegradability of new magnetic resonance imaging (MRI) contrast agents is high-ly desired. The superparamagnetic iron oxide (SPIO) nanoparticles are suitable candidates for these pur-poses. Here the co-precipitation technique for synthesis of monodispersed SPIO nanoparticles is pre-sented. The critical point of the synthesis is core formation and consequent crystal growth. The conditions for core formation (time, temperature, rate of base addition) were optimised. The nanoparticles were stabilised by either silanisation or polymer coating (cationic chitosan, poly-D-Arg, dextran, gelatine, hyaluronic acid). The stability was investigated in physiological pH, different ionic strength solutions, PBS-albumine solution or blood plasma. The biocompatibility was tested in vitro either in the presence of Saccharomyces cerevisiae or erythrocytes suspension. The size and shape was investigated by atomic force microscopy (AFM) and scanning electron microscopy (SEM). The molecular struc The biocompatibility and biodegradability of new magnetic resonance imaging (MRI) contrast agents is high-ly desired. The superparamagnetic iron oxide (SPIO) nanoparticles are suitable candidates for these pur-poses. Here the co-precipitation technique for synthesis of monodispersed SPIO nanoparticles is pre-sented. The critical point of the synthesis is core formation and consequent crystal growth. The conditions for core formation (time, temperature, rate of base addition) were optimised. The nanoparticles were stabilised by either silanisation or polymer coating (cationic chitosan, poly-D-Arg, dextran, gelatine, hyaluronic acid). The stability was investigated in physiological pH, different ionic strength solutions, PBS-albumine solution or blood plasma. The biocompatibility was tested in vitro either in the presence of Saccharomyces cerevisiae or erythrocytes suspension. The size and shape was investigated by atomic force microscopy (AFM) and scanning electron microscopy (SEM). The molecular struc
dcterms:title
The Synthesis, Surface Modification and Stability of SPIO Nanoparticles for MRI Application The Synthesis, Surface Modification and Stability of SPIO Nanoparticles for MRI Application
skos:prefLabel
The Synthesis, Surface Modification and Stability of SPIO Nanoparticles for MRI Application The Synthesis, Surface Modification and Stability of SPIO Nanoparticles for MRI Application
skos:notation
RIV/00216305:26310/13:PU105842!RIV14-MSM-26310___
n9:predkladatel
n10:orjk%3A26310
n3:aktivita
n17:S
n3:aktivity
S
n3:dodaniDat
n13:2014
n3:domaciTvurceVysledku
n4:5307112
n3:druhVysledku
n7:O
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
109572
n3:idVysledku
RIV/00216305:26310/13:PU105842
n3:jazykVysledku
n11:eng
n3:klicovaSlova
nanoparticles, surface modification, stability, particle size, particle shape, structure
n3:klicoveSlovo
n8:nanoparticles n8:particle%20size n8:particle%20shape n8:stability n8:structure n8:surface%20modification
n3:kontrolniKodProRIV
[EA81A19BB9DD]
n3:obor
n15:CF
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n13:2013
n3:tvurceVysledku
Skládal, Petr Malá, Aneta Kalina, Michal Fohlerová, Zdenka Jiřík, Radovan Kovář, David Starčuk, Zenon
n12:organizacniJednotka
26310