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Statements

Subject Item
n2:RIV%2F00216305%3A26310%2F12%3APU99098%21RIV13-MSM-26310___
rdf:type
n3:Vysledek skos:Concept
dcterms:description
Chiral pharmaceuticals are known to exhibit stereoselective behaviour when situated in a biological system (e.g. living organism) resulting in enantiomers of these compounds showing different biological properties such as toxicity. For better understanding of the fate of chiral pharmaceuticals in the environment it is of great importance to develop chiral analytical methods capable of trace analysis in the environmental matrices. Enantioselective HPLC-DAD method was developed for the analysis of two non-steroidal anti-inflammatory drugs: ibuprofen and ketoprofen. Enantiomers of these compounds were separated using Chiralpak AD as a chiral column in the normal phase mode. Extracted samples of raw and treated wastewater were at first analysed by achiral HPLC-ESI-MS method, which was used for quantification of the sum of ibuprofen and ketoprofen enantiomers. After this, the samples were analyzed by chiral HPLC using diode array detector. It was found out that the diode array detector is not sensitive an Chiral pharmaceuticals are known to exhibit stereoselective behaviour when situated in a biological system (e.g. living organism) resulting in enantiomers of these compounds showing different biological properties such as toxicity. For better understanding of the fate of chiral pharmaceuticals in the environment it is of great importance to develop chiral analytical methods capable of trace analysis in the environmental matrices. Enantioselective HPLC-DAD method was developed for the analysis of two non-steroidal anti-inflammatory drugs: ibuprofen and ketoprofen. Enantiomers of these compounds were separated using Chiralpak AD as a chiral column in the normal phase mode. Extracted samples of raw and treated wastewater were at first analysed by achiral HPLC-ESI-MS method, which was used for quantification of the sum of ibuprofen and ketoprofen enantiomers. After this, the samples were analyzed by chiral HPLC using diode array detector. It was found out that the diode array detector is not sensitive an
dcterms:title
Chiral Analysis of the Nonsteroidal Anti-inflammatory Drug Residuals in the Wastewater Chiral Analysis of the Nonsteroidal Anti-inflammatory Drug Residuals in the Wastewater
skos:prefLabel
Chiral Analysis of the Nonsteroidal Anti-inflammatory Drug Residuals in the Wastewater Chiral Analysis of the Nonsteroidal Anti-inflammatory Drug Residuals in the Wastewater
skos:notation
RIV/00216305:26310/12:PU99098!RIV13-MSM-26310___
n3:predkladatel
n8:orjk%3A26310
n4:aktivita
n15:S
n4:aktivity
S
n4:dodaniDat
n11:2013
n4:domaciTvurceVysledku
n9:8551987 n9:9179399
n4:druhVysledku
n10:O
n4:duvernostUdaju
n17:S
n4:entitaPredkladatele
n14:predkladatel
n4:idSjednocenehoVysledku
126997
n4:idVysledku
RIV/00216305:26310/12:PU99098
n4:jazykVysledku
n7:eng
n4:klicovaSlova
chirality, chiral pharmaceuticals, wastewater, HPLC, ibuprofen, ketoprofen, chiralpak AD
n4:klicoveSlovo
n5:ibuprofen n5:HPLC n5:chiral%20pharmaceuticals n5:chirality n5:wastewater n5:ketoprofen n5:chiralpak%20AD
n4:kontrolniKodProRIV
[701536627018]
n4:obor
n16:CB
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
2
n4:rokUplatneniVysledku
n11:2012
n4:tvurceVysledku
Čáslavský, Josef Svobodová, Dagmar
n13:organizacniJednotka
26310