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Statements

Subject Item
n2:RIV%2F00216305%3A26230%2F14%3APU111943%21RIV15-MSM-26230___
rdf:type
skos:Concept n15:Vysledek
dcterms:description
Eukaryotic genomes are rich in sequences capable of forming non-B DNA structures. These structures are expected to play important roles in natural regulatory processes at levels above those of individual genes, such as whole genome dynamics or chromatin organization, as well as in processes leading to the loss of these functions, such as cancer development. Recently, a number of authors have mapped the occurrence of potential quadruplex sequences in the human genome and found them to be associated with promoters. In this paper, we set out to map the distribution and characteristics of potential triplex-forming sequences in human genome DNA sequences. Using the R/Bioconductor package triplex, we found these sequences to be excluded from exons, while present mostly in a small number of repetitive sequence classes, especially short sequence tandem repeats (microsatellites), Alu and combined elements, such as SVA. We also introduce a novel way of classifying potential triplex sequences, using Eukaryotic genomes are rich in sequences capable of forming non-B DNA structures. These structures are expected to play important roles in natural regulatory processes at levels above those of individual genes, such as whole genome dynamics or chromatin organization, as well as in processes leading to the loss of these functions, such as cancer development. Recently, a number of authors have mapped the occurrence of potential quadruplex sequences in the human genome and found them to be associated with promoters. In this paper, we set out to map the distribution and characteristics of potential triplex-forming sequences in human genome DNA sequences. Using the R/Bioconductor package triplex, we found these sequences to be excluded from exons, while present mostly in a small number of repetitive sequence classes, especially short sequence tandem repeats (microsatellites), Alu and combined elements, such as SVA. We also introduce a novel way of classifying potential triplex sequences, using
dcterms:title
Uneven distribution of potential triplex sequences in the human genome: In silico study using the R/Bioconductor package triplex Uneven distribution of potential triplex sequences in the human genome: In silico study using the R/Bioconductor package triplex
skos:prefLabel
Uneven distribution of potential triplex sequences in the human genome: In silico study using the R/Bioconductor package triplex Uneven distribution of potential triplex sequences in the human genome: In silico study using the R/Bioconductor package triplex
skos:notation
RIV/00216305:26230/14:PU111943!RIV15-MSM-26230___
n5:aktivita
n13:S n13:P
n5:aktivity
P(ED1.1.00/02.0070), P(EE2.3.20.0189), S
n5:dodaniDat
n19:2015
n5:domaciTvurceVysledku
n9:4123484
n5:druhVysledku
n18:D
n5:duvernostUdaju
n6:S
n5:entitaPredkladatele
n12:predkladatel
n5:idSjednocenehoVysledku
51932
n5:idVysledku
RIV/00216305:26230/14:PU111943
n5:jazykVysledku
n16:eng
n5:klicovaSlova
Human genome, DNA sequence, Non-B-DNA, Triplex, Bioconductor, Repetitive sequences, Mobile DNA, Lexicographically minimal rotation
n5:klicoveSlovo
n8:Bioconductor n8:Non-B-DNA n8:Lexicographically%20minimal%20rotation n8:Triplex n8:Mobile%20DNA n8:Human%20genome n8:Repetitive%20sequences n8:DNA%20sequence
n5:kontrolniKodProRIV
[79E629968F65]
n5:mistoKonaniAkce
Angers
n5:mistoVydani
Angers
n5:nazevZdroje
Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms
n5:obor
n11:IN
n5:pocetDomacichTvurcuVysledku
1
n5:pocetTvurcuVysledku
3
n5:projekt
n22:EE2.3.20.0189 n22:ED1.1.00%2F02.0070
n5:rokUplatneniVysledku
n19:2014
n5:tvurceVysledku
Lexa, Matej Martínek, Tomáš Brázdová, Marie
n5:typAkce
n17:WRD
n5:zahajeniAkce
2014-03-03+01:00
s:numberOfPages
9
n20:doi
10.5220/0004824100800088
n21:hasPublisher
SciTePress - Science and Technology Publications
n4:isbn
978-989-758-012-3
n10:organizacniJednotka
26230