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Statements

Subject Item
n2:RIV%2F00216305%3A26230%2F12%3APU101764%21RIV13-MSM-26230___
rdf:type
skos:Concept n17:Vysledek
dcterms:description
This paper describes a new integrative system for ranking non-synonymous protein substitutions by their deleterious effects. The computational core of the proposed system is based on a sophisticated combination of results from the selected subset of existing tools. The weight coefficients for individual tools are calculated on the basis of their confidence score and the tool reliability which are assigned accordingly to the tool performance measured on the extensive dataset. The performance validation on the dataset consisting of 5000 substitutions shows that overall accuracy of the system was improved by 8% in comparison to the best of the integrated methods. This paper describes a new integrative system for ranking non-synonymous protein substitutions by their deleterious effects. The computational core of the proposed system is based on a sophisticated combination of results from the selected subset of existing tools. The weight coefficients for individual tools are calculated on the basis of their confidence score and the tool reliability which are assigned accordingly to the tool performance measured on the extensive dataset. The performance validation on the dataset consisting of 5000 substitutions shows that overall accuracy of the system was improved by 8% in comparison to the best of the integrated methods.
dcterms:title
Integration System for Functional Annotation of Single Nucleotide Polymorphism Integration System for Functional Annotation of Single Nucleotide Polymorphism
skos:prefLabel
Integration System for Functional Annotation of Single Nucleotide Polymorphism Integration System for Functional Annotation of Single Nucleotide Polymorphism
skos:notation
RIV/00216305:26230/12:PU101764!RIV13-MSM-26230___
n17:predkladatel
n18:orjk%3A26230
n3:aktivita
n10:S n10:P n10:Z
n3:aktivity
P(ED1.1.00/02.0070), S, Z(MSM0021630528)
n3:cisloPeriodika
5
n3:dodaniDat
n14:2013
n3:domaciTvurceVysledku
n6:3725340 n6:9190066
n3:druhVysledku
n11:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
142130
n3:idVysledku
RIV/00216305:26230/12:PU101764
n3:jazykVysledku
n8:eng
n3:klicovaSlova
SNP, nsSNP, pathogenicity prediction, protein substitutions
n3:klicoveSlovo
n4:SNP n4:nsSNP n4:protein%20substitutions n4:pathogenicity%20prediction
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[0E6F71687713]
n3:nazevZdroje
ElectroScope - http://www.electroscope.zcu.cz
n3:obor
n19:IN
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:projekt
n5:ED1.1.00%2F02.0070
n3:rokUplatneniVysledku
n14:2012
n3:svazekPeriodika
2012
n3:tvurceVysledku
Zendulka, Jaroslav Bendl, Jaroslav
n3:zamer
n16:MSM0021630528
s:issn
1802-4564
s:numberOfPages
5
n20:organizacniJednotka
26230