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Statements

Subject Item
n2:RIV%2F00216305%3A26220%2F09%3APU82547%21RIV10-MSM-26220___
rdf:type
n9:Vysledek skos:Concept
dcterms:description
Cardiovascular system diseases are frequent cause of morbidity and mortality in Western countries. In our laboratory, early stages of ischemia - prominent diagnosis in this group - are examined by recording electrograms and action potentials by optical probe in isolated mammalian hearts loaded with voltage-sensitive dye (VSD) di-4-ANEPPS. In this study, guinea pig and rabbit isolated hearts were exposed to special protocol of s.-c. preconditioning - attenuation of the symptoms during repeated exposure to ischemic insult. In guinea pig myocardium, additive effect of VSD and ischemia triggered more serious and more frequent arrhythmias then the same situation in rabbit hearts. Moreover, expected attenuation of these effects was not observed, on the contrary to rabbit myocardium, where typical preconditioning was present. Rabbit myocardium appears to be more suitable for studies in such experimental design. Cardiovascular system diseases are frequent cause of morbidity and mortality in Western countries. In our laboratory, early stages of ischemia - prominent diagnosis in this group - are examined by recording electrograms and action potentials by optical probe in isolated mammalian hearts loaded with voltage-sensitive dye (VSD) di-4-ANEPPS. In this study, guinea pig and rabbit isolated hearts were exposed to special protocol of s.-c. preconditioning - attenuation of the symptoms during repeated exposure to ischemic insult. In guinea pig myocardium, additive effect of VSD and ischemia triggered more serious and more frequent arrhythmias then the same situation in rabbit hearts. Moreover, expected attenuation of these effects was not observed, on the contrary to rabbit myocardium, where typical preconditioning was present. Rabbit myocardium appears to be more suitable for studies in such experimental design.
dcterms:title
Model of Preconditioning in Guinea Pig and Rabbit Isolated Hearts Loaded with Voltage-Sensitive Dye Di-4-ANEPPS Model of Preconditioning in Guinea Pig and Rabbit Isolated Hearts Loaded with Voltage-Sensitive Dye Di-4-ANEPPS
skos:prefLabel
Model of Preconditioning in Guinea Pig and Rabbit Isolated Hearts Loaded with Voltage-Sensitive Dye Di-4-ANEPPS Model of Preconditioning in Guinea Pig and Rabbit Isolated Hearts Loaded with Voltage-Sensitive Dye Di-4-ANEPPS
skos:notation
RIV/00216305:26220/09:PU82547!RIV10-MSM-26220___
n4:aktivita
n12:Z n12:P
n4:aktivity
P(GA102/07/1473), P(GP102/07/P521), Z(MSM0021630513)
n4:dodaniDat
n15:2010
n4:domaciTvurceVysledku
n5:4096541 n5:8088586 n5:5074169
n4:druhVysledku
n17:D
n4:duvernostUdaju
n10:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
326688
n4:idVysledku
RIV/00216305:26220/09:PU82547
n4:jazykVysledku
n20:eng
n4:klicovaSlova
Electrogram, monophasic action potential, animal experiment, cardiology research
n4:klicoveSlovo
n13:animal%20experiment n13:cardiology%20research n13:Electrogram n13:monophasic%20action%20potential
n4:kontrolniKodProRIV
[91E7E166A6AB]
n4:mistoKonaniAkce
Park City, Utah
n4:mistoVydani
Park City, Utah
n4:nazevZdroje
Computers in Cardiology
n4:obor
n19:JD
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
5
n4:projekt
n14:GA102%2F07%2F1473 n14:GP102%2F07%2FP521
n4:rokUplatneniVysledku
n15:2009
n4:tvurceVysledku
Kolářová, Jana Provazník, Ivo Fialová, Kateřina Nováková, Marie
n4:typAkce
n22:WRD
n4:zahajeniAkce
2009-09-13+02:00
n4:zamer
n8:MSM0021630513
s:numberOfPages
4
n18:hasPublisher
IEEE
n7:isbn
0-7803-8894-1
n21:organizacniJednotka
26220