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Statements

Subject Item
n2:RIV%2F00216305%3A26220%2F08%3APU76141%21RIV10-MSM-26220___
rdf:type
n11:Vysledek skos:Concept
dcterms:description
Parapapillary atrophy is an important clinical sign associated with progressive optic disc damage and visual field loss in patients with glaucoma. Histologic and spectroscopic results revealed an accumulation of lipofuscin as the dominant fundus fluorophore localized in the lysosomes of the retinal pigmentepithelium in the parapapillary atrophic zone. We investigated morphologic characteristics of parapapillary autofluorescence in patients with different entities and stages of glaucoma compared to healthy controls using Scanning Laser Ophthalmoscopy. Autofluorescence was measured with HRA standard software and compared to a new semiautomatic approach. Both, area and mean distance of the autofluorescence regions from the optic disc border were well associated with increasing glaucomatous damage. Changes were more pronounced for early stages. Semiautomatic segmentation improved interobserver variability. Parapapillary atrophy is an important clinical sign associated with progressive optic disc damage and visual field loss in patients with glaucoma. Histologic and spectroscopic results revealed an accumulation of lipofuscin as the dominant fundus fluorophore localized in the lysosomes of the retinal pigmentepithelium in the parapapillary atrophic zone. We investigated morphologic characteristics of parapapillary autofluorescence in patients with different entities and stages of glaucoma compared to healthy controls using Scanning Laser Ophthalmoscopy. Autofluorescence was measured with HRA standard software and compared to a new semiautomatic approach. Both, area and mean distance of the autofluorescence regions from the optic disc border were well associated with increasing glaucomatous damage. Changes were more pronounced for early stages. Semiautomatic segmentation improved interobserver variability. Parapapillary atrophy is an important clinical sign associated with progressive optic disc damage and visual field loss in patients with glaucoma. Histologic and spectroscopic results revealed an accumulation of lipofuscin as the dominant fundus fluorophore localized in the lysosomes of the retinal pigmentepithelium in the parapapillary atrophic zone. We investigated morphologic characteristics of parapapillary autofluorescence in patients with different entities and stages of glaucoma compared to healthy controls using Scanning Laser Ophthalmoscopy. Autofluorescence was measured with HRA standard software and compared to a new semiautomatic approach. Both, area and mean distance of the autofluorescence regions from the optic disc border were well associated with increasing glaucomatous damage. Changes were more pronounced for early stages. Semiautomatic segmentation improved interobserver variability.
dcterms:title
Impact Of Parapapillary Autofluorescence In Glaucoma: Clinical Aspects Impact Of Parapapillary Autofluorescence In Glaucoma: Clinical Aspects Impact Of Parapapillary Autofluorescence In Glaucoma: Clinical Aspects
skos:prefLabel
Impact Of Parapapillary Autofluorescence In Glaucoma: Clinical Aspects Impact Of Parapapillary Autofluorescence In Glaucoma: Clinical Aspects Impact Of Parapapillary Autofluorescence In Glaucoma: Clinical Aspects
skos:notation
RIV/00216305:26220/08:PU76141!RIV10-MSM-26220___
n3:aktivita
n12:P n12:Z
n3:aktivity
P(1M0572), Z(MSM0021630513)
n3:cisloPeriodika
1
n3:dodaniDat
n4:2010
n3:domaciTvurceVysledku
n5:7927185 n5:2409879
n3:druhVysledku
n13:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
371514
n3:idVysledku
RIV/00216305:26220/08:PU76141
n3:jazykVysledku
n19:cze
n3:klicovaSlova
glaucoma, retinal imaging, autofluorescence
n3:klicoveSlovo
n9:glaucoma n9:autofluorescence n9:retinal%20imaging
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[A31A47DE906D]
n3:nazevZdroje
Analysis of Biomedical Signals and Images
n3:obor
n17:JA
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
4
n3:projekt
n16:1M0572
n3:rokUplatneniVysledku
n4:2008
n3:svazekPeriodika
19
n3:tvurceVysledku
Jan, Jiří Mardin, Christian Y Kolář, Radim Laemmer, Robert
n3:zamer
n18:MSM0021630513
s:issn
1211-412X
s:numberOfPages
4
n7:organizacniJednotka
26220