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Statements

Subject Item
n2:RIV%2F00216305%3A26220%2F08%3APU71089%21RIV10-MSM-26220___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
The transverse-axial tubular system (TATS) of cardiac ventricular myocytes is a complex network of tubules that arises as invaginations of the surface membrane; it appears to form a specialised region of cell membrane that is particularly important for excitation-contraction coupling. However much remains unknown about the structure and role of the TATS. In this brief review we use experimental data and computer modelling to address the following key questions: (i) What fraction of the cell membrane is within the TATS? (ii) Is the composition of the TATS membrane the same as the surface membrane? (iii) How good is electrical coupling between the surface and TATS membranes? (iv) What fraction of each current is within the TATS? (v) How important is the complex structure of the TATS network? (vi) What is the effect of current inhomogeneity on lumenal ion concentrations? (vii) Does the TATS contribute to the functional changes observed in heart failure? Although there are many areas in which experimental The transverse-axial tubular system (TATS) of cardiac ventricular myocytes is a complex network of tubules that arises as invaginations of the surface membrane; it appears to form a specialised region of cell membrane that is particularly important for excitation-contraction coupling. However much remains unknown about the structure and role of the TATS. In this brief review we use experimental data and computer modelling to address the following key questions: (i) What fraction of the cell membrane is within the TATS? (ii) Is the composition of the TATS membrane the same as the surface membrane? (iii) How good is electrical coupling between the surface and TATS membranes? (iv) What fraction of each current is within the TATS? (v) How important is the complex structure of the TATS network? (vi) What is the effect of current inhomogeneity on lumenal ion concentrations? (vii) Does the TATS contribute to the functional changes observed in heart failure? Although there are many areas in which experimental
dcterms:title
Modelling the cardiac transverse-axial tubular system Modelling the cardiac transverse-axial tubular system
skos:prefLabel
Modelling the cardiac transverse-axial tubular system Modelling the cardiac transverse-axial tubular system
skos:notation
RIV/00216305:26220/08:PU71089!RIV10-MSM-26220___
n3:aktivita
n18:Z
n3:aktivity
Z(AV0Z20760514), Z(MSM0021622402), Z(MSM0021630513)
n3:cisloPeriodika
1-3
n3:dodaniDat
n8:2010
n3:domaciTvurceVysledku
n17:7773625
n3:druhVysledku
n14:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
380001
n3:idVysledku
RIV/00216305:26220/08:PU71089
n3:jazykVysledku
n15:eng
n3:klicovaSlova
t-tubules, TATS, Heart, Calcium, Ventricle, Computer model
n3:klicoveSlovo
n5:Computer%20model n5:Heart n5:TATS n5:Calcium n5:Ventricle n5:t-tubules
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[30907CF4F5C8]
n3:nazevZdroje
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
n3:obor
n13:BO
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
2
n3:rokUplatneniVysledku
n8:2008
n3:svazekPeriodika
2008 (96)
n3:tvurceVysledku
Pásek, Michal Šimurda, Jiří
n3:zamer
n11:MSM0021622402 n11:MSM0021630513 n11:AV0Z20760514
s:issn
0079-6107
s:numberOfPages
18
n9:organizacniJednotka
26220