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Statements

Subject Item
n2:RIV%2F00216305%3A26220%2F06%3APU62586%21RIV06-GA0-26220___
rdf:type
n3:Vysledek skos:Concept
dcterms:description
Cardiac sigma receptors are involved in fine modulation of contractility in mammalian myocardium. Their role in the changes of cardiac excitability is studied using various experimental models. In this study, the effect of sigma receptor ligand, psychotropic drug haloperidol, was examined in isolated guinea pig hearts perfused according to Langendorff. Electrogram and coronary flow changes were followed in control and during two administrations of haloperidol. Prolongation of QT interval was found in thhe first, but not in the second haloperidol application. It is concluded, that sigma ligand haloperidol affects repolarization phase of cardiac electrogram and this process may explain various rhythm disturbances reported in patients treated with haloperidol. Cardiac sigma receptors are involved in fine modulation of contractility in mammalian myocardium. Their role in the changes of cardiac excitability is studied using various experimental models. In this study, the effect of sigma receptor ligand, psychotropic drug haloperidol, was examined in isolated guinea pig hearts perfused according to Langendorff. Electrogram and coronary flow changes were followed in control and during two administrations of haloperidol. Prolongation of QT interval was found in thhe first, but not in the second haloperidol application. It is concluded, that sigma ligand haloperidol affects repolarization phase of cardiac electrogram and this process may explain various rhythm disturbances reported in patients treated with haloperidol. Cardiac sigma receptors are involved in fine modulation of contractility in mammalian myocardium. Their role in the changes of cardiac excitability is studied using various experimental models. In this study, the effect of sigma receptor ligand, psychotropic drug haloperidol, was examined in isolated guinea pig hearts perfused according to Langendorff. Electrogram and coronary flow changes were followed in control and during two administrations of haloperidol. Prolongation of QT interval was found in thhe first, but not in the second haloperidol application. It is concluded, that sigma ligand haloperidol affects repolarization phase of cardiac electrogram and this process may explain various rhythm disturbances reported in patients treated with haloperidol.
dcterms:title
Effect of Sigma Receptor Ligand Haloperidol on Guinea Pig Isolated Heart Electrogram Effect of Sigma Receptor Ligand Haloperidol on Guinea Pig Isolated Heart Electrogram Effect of Sigma Receptor Ligand Haloperidol on Guinea Pig Isolated Heart Electrogram
skos:prefLabel
Effect of Sigma Receptor Ligand Haloperidol on Guinea Pig Isolated Heart Electrogram Effect of Sigma Receptor Ligand Haloperidol on Guinea Pig Isolated Heart Electrogram Effect of Sigma Receptor Ligand Haloperidol on Guinea Pig Isolated Heart Electrogram
skos:notation
RIV/00216305:26220/06:PU62586!RIV06-GA0-26220___
n4:strany
1-4
n4:aktivita
n20:Z n20:P
n4:aktivity
P(GA102/04/0472), P(GA305/04/1385), Z(MSM0021630513)
n4:dodaniDat
n18:2006
n4:domaciTvurceVysledku
n8:8088586 n8:1469517 n8:4096541
n4:druhVysledku
n10:D
n4:duvernostUdaju
n19:S
n4:entitaPredkladatele
n17:predkladatel
n4:idSjednocenehoVysledku
473196
n4:idVysledku
RIV/00216305:26220/06:PU62586
n4:jazykVysledku
n7:eng
n4:klicovaSlova
sigma receptor, haloperidol, isolated heart, electrogram
n4:klicoveSlovo
n12:electrogram n12:haloperidol n12:isolated%20heart n12:sigma%20receptor
n4:kontrolniKodProRIV
[72F7924AA376]
n4:mistoKonaniAkce
Valencia
n4:mistoVydani
Valencia
n4:nazevZdroje
Computers in Cardiology 2006
n4:obor
n22:JD
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
3
n4:projekt
n11:GA102%2F04%2F0472 n11:GA305%2F04%2F1385
n4:rokUplatneniVysledku
n18:2006
n4:tvurceVysledku
Bardoňová, Jana Provazník, Ivo Nováková, Marie
n4:typAkce
n5:WRD
n4:zahajeniAkce
2006-09-17+02:00
n4:zamer
n14:MSM0021630513
s:numberOfPages
4
n21:hasPublisher
IEEE
n16:isbn
0-7803-8894-1
n9:organizacniJednotka
26220