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Statements

Subject Item
n2:RIV%2F00216305%3A26210%2F13%3APU106786%21RIV14-GA0-26210___
rdf:type
skos:Concept n6:Vysledek
dcterms:description
It seems to be very convenient to receive a medicine by inhalation instead of injection. Unfortunately transport of particles and targeted delivery of a drug in human respiratory airways is very complicated task. Therefore we carried out experiments and tested different methods for evaluation of particle deposition in a model of human lungs. The model included respiratory airways from oral cavity to 7th generation of branching. Particles were dispersed by TSI Small-scale Powder Disperser 3433 and delivered to the model. The model was disassembled into segments after the deposition of the particles and local deposition was measured. Two methods were used to analyse the samples, fluorescence spectroscopy and optical microscopy. The first method was based on measuring the intensity of luminescence, which represented the particle deposition. The second method used the optical microscope with phase-contrast objective. A dispersion of isopropanol and particles was filtrated using a vacuum filtration unit, a It seems to be very convenient to receive a medicine by inhalation instead of injection. Unfortunately transport of particles and targeted delivery of a drug in human respiratory airways is very complicated task. Therefore we carried out experiments and tested different methods for evaluation of particle deposition in a model of human lungs. The model included respiratory airways from oral cavity to 7th generation of branching. Particles were dispersed by TSI Small-scale Powder Disperser 3433 and delivered to the model. The model was disassembled into segments after the deposition of the particles and local deposition was measured. Two methods were used to analyse the samples, fluorescence spectroscopy and optical microscopy. The first method was based on measuring the intensity of luminescence, which represented the particle deposition. The second method used the optical microscope with phase-contrast objective. A dispersion of isopropanol and particles was filtrated using a vacuum filtration unit, a
dcterms:title
Comparison of methods for evaluation of aerosol deposition in the model of human lungs Comparison of methods for evaluation of aerosol deposition in the model of human lungs
skos:prefLabel
Comparison of methods for evaluation of aerosol deposition in the model of human lungs Comparison of methods for evaluation of aerosol deposition in the model of human lungs
skos:notation
RIV/00216305:26210/13:PU106786!RIV14-GA0-26210___
n6:predkladatel
n7:orjk%3A26210
n5:aktivita
n8:P
n5:aktivity
P(ED0002/01/01), P(GAP105/11/1339)
n5:dodaniDat
n17:2014
n5:domaciTvurceVysledku
n16:1060910 n16:7609493 n16:6476988 n16:7853750 n16:4040619
n5:druhVysledku
n13:D
n5:duvernostUdaju
n21:S
n5:entitaPredkladatele
n19:predkladatel
n5:idSjednocenehoVysledku
66251
n5:idVysledku
RIV/00216305:26210/13:PU106786
n5:jazykVysledku
n14:eng
n5:klicovaSlova
Aerosol deposition, optical microscopy, fluorescent spectroscopy, human lungs
n5:klicoveSlovo
n9:human%20lungs n9:fluorescent%20spectroscopy n9:Aerosol%20deposition n9:optical%20microscopy
n5:kontrolniKodProRIV
[03662EF1C79D]
n5:mistoKonaniAkce
Kutná Hora
n5:mistoVydani
Kutná hora
n5:nazevZdroje
International Conference Experimental Fluid Mechanics 2013
n5:obor
n15:BK
n5:pocetDomacichTvurcuVysledku
5
n5:pocetTvurcuVysledku
5
n5:projekt
n22:GAP105%2F11%2F1339 n22:ED0002%2F01%2F01
n5:rokUplatneniVysledku
n17:2013
n5:tvurceVysledku
Bělka, Miloslav Jícha, Miroslav Lízal, František Lippay, Josef Jedelský, Jan
n5:typAkce
n11:WRD
n5:zahajeniAkce
2013-11-19+01:00
s:numberOfPages
4
n20:hasPublisher
Technical university of Liberec
n18:isbn
978-80-260-5375-0
n10:organizacniJednotka
26210