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Statements

Subject Item
n2:RIV%2F00216305%3A26210%2F09%3APU85445%21RIV10-MSM-26210___
rdf:type
skos:Concept n12:Vysledek
dcterms:description
Metallomics and metalloproteomics are emerging fields addressing the role, uptake, transport and storage of trace metals essential for life. There are several main approaches that are being developed in metallomics and metalloproteomics including both detection of levels and spatial distribution of heavy metals and determination of heavy-metal-contained proteins. The aim of this work is detection of copper and zinc in healthy and tumour tissues of miniature pigs by using of the laser induced breakdown spectroscopy (LIBS). Concentration of heavy metal transporting protein metallothionein (MT) was determined by Brdicka reaction. Tissue cryosections were obtained from the MeLiM strain of miniature pigs with hereditary melanoma, particularly from healthy skin, cutaneous nodular melanomas and metastases in the liver, spleen and lymph nodes. Using LIBS we measured maps of spatial distribution of the essential heavy metals in cryosections and found that the maps of healthy and tumour cryosection markedly dif Metallomics and metalloproteomics are emerging fields addressing the role, uptake, transport and storage of trace metals essential for life. There are several main approaches that are being developed in metallomics and metalloproteomics including both detection of levels and spatial distribution of heavy metals and determination of heavy-metal-contained proteins. The aim of this work is detection of copper and zinc in healthy and tumour tissues of miniature pigs by using of the laser induced breakdown spectroscopy (LIBS). Concentration of heavy metal transporting protein metallothionein (MT) was determined by Brdicka reaction. Tissue cryosections were obtained from the MeLiM strain of miniature pigs with hereditary melanoma, particularly from healthy skin, cutaneous nodular melanomas and metastases in the liver, spleen and lymph nodes. Using LIBS we measured maps of spatial distribution of the essential heavy metals in cryosections and found that the maps of healthy and tumour cryosection markedly dif
dcterms:title
Metallomics of melanoma animal tissues Metallomics of melanoma animal tissues
skos:prefLabel
Metallomics of melanoma animal tissues Metallomics of melanoma animal tissues
skos:notation
RIV/00216305:26210/09:PU85445!RIV10-MSM-26210___
n3:aktivita
n8:S
n3:aktivity
S
n3:cisloPeriodika
Suppl. 1
n3:dodaniDat
n10:2010
n3:domaciTvurceVysledku
n4:6620477
n3:druhVysledku
n13:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
325613
n3:idVysledku
RIV/00216305:26210/09:PU85445
n3:jazykVysledku
n15:eng
n3:klicovaSlova
metallomics, LIBS, electrochemistry, melanoma
n3:klicoveSlovo
n7:electrochemistry n7:LIBS n7:melanoma n7:metallomics
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[8A10F82AF69B]
n3:nazevZdroje
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
n3:obor
n14:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
12
n3:rokUplatneniVysledku
n10:2009
n3:svazekPeriodika
24
n3:tvurceVysledku
Kaiser, Jozef
s:issn
1107-3756
s:numberOfPages
1
n17:organizacniJednotka
26210