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Statements

Subject Item
n2:RIV%2F00216275%3A25310%2F14%3A39898292%21RIV15-MSM-25310___
rdf:type
n14:Vysledek skos:Concept
dcterms:description
Uric acid is the final product of human purine metabolism. It was pointed out that this compound acts as an antioxidant and is able to react with reactive oxygen species forming allantoin. Therefore, the measurement of allantoin levels may be used for the determination of oxidative stress in humans. The aim of the study was to clarify the antioxidant effect of uric acid during intense exercise. Whole blood samples were obtained from a group of healthy subjects. Allantoin, uric acid, and malondialdehyde levels in plasma and erythrocytes were measured using a HPLC with UV/Vis detection. Statistical significant differences in allantoin and uric acid levels during short-term intense exercise were found. Immediately after intense exercise, the plasma allantoin levels increased on the average of 200 % in comparison to baseline. Plasma uric acid levels increased slowly, at an average of 20 %. On the other hand, there were no significant changes in plasma malondialdehyde. The results suggest that uric acid, important antioxidant, is probably oxidized by reactive oxygen species to allantoin. Therefore allantoin may be suitable candidate for a marker of acute oxidative stress. Uric acid is the final product of human purine metabolism. It was pointed out that this compound acts as an antioxidant and is able to react with reactive oxygen species forming allantoin. Therefore, the measurement of allantoin levels may be used for the determination of oxidative stress in humans. The aim of the study was to clarify the antioxidant effect of uric acid during intense exercise. Whole blood samples were obtained from a group of healthy subjects. Allantoin, uric acid, and malondialdehyde levels in plasma and erythrocytes were measured using a HPLC with UV/Vis detection. Statistical significant differences in allantoin and uric acid levels during short-term intense exercise were found. Immediately after intense exercise, the plasma allantoin levels increased on the average of 200 % in comparison to baseline. Plasma uric acid levels increased slowly, at an average of 20 %. On the other hand, there were no significant changes in plasma malondialdehyde. The results suggest that uric acid, important antioxidant, is probably oxidized by reactive oxygen species to allantoin. Therefore allantoin may be suitable candidate for a marker of acute oxidative stress.
dcterms:title
A monitorong of allantoin, uric acid, and malondialdehyde levels in plasma and erythrocytes after ten minutes of running activity A monitorong of allantoin, uric acid, and malondialdehyde levels in plasma and erythrocytes after ten minutes of running activity
skos:prefLabel
A monitorong of allantoin, uric acid, and malondialdehyde levels in plasma and erythrocytes after ten minutes of running activity A monitorong of allantoin, uric acid, and malondialdehyde levels in plasma and erythrocytes after ten minutes of running activity
skos:notation
RIV/00216275:25310/14:39898292!RIV15-MSM-25310___
n3:aktivita
n13:S n13:I
n3:aktivity
I, S
n3:cisloPeriodika
6
n3:dodaniDat
n15:2015
n3:domaciTvurceVysledku
n10:7332580 n10:2726955 n10:8771928
n3:druhVysledku
n11:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
852
n3:idVysledku
RIV/00216275:25310/14:39898292
n3:jazykVysledku
n5:eng
n3:klicovaSlova
short-term intense exercise; antioxidants; oxidative stress; uric acid; allantoin
n3:klicoveSlovo
n4:short-term%20intense%20exercise n4:oxidative%20stress n4:allantoin n4:antioxidants n4:uric%20acid
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[3D5B493D6041]
n3:nazevZdroje
Physiological Reasearch
n3:obor
n17:CE
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n15:2014
n3:svazekPeriodika
63
n3:tvurceVysledku
Křenková, Jana Štramová, Xenie Drábková, Petra Kanďár, Roman
n3:wos
000347371200009
s:issn
0862-8408
s:numberOfPages
10
n8:organizacniJednotka
25310