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Statements

Subject Item
n2:RIV%2F00216275%3A25310%2F14%3A39898015%21RIV15-MSM-25310___
rdf:type
skos:Concept n15:Vysledek
dcterms:description
Voltammetric behavior of a wide-spread used chemotherapeutic drug methotrexate (MTX) has been investigated on a polished silver solid amalgam electrode (p-AgSAE) employing various voltammetric methods like cyclic voltammetry, direct current voltammetry and differential pulse voltammetry. It was found that MTX provided two reduction and one oxidation peak in an acidic medium and the positively situated reduction signal (Ep = -340 mV), due its favorable analytical properties, was studied more in detail. 0.05 mol L-1 acetate buffer of pH 5 was selected as an optimal medium for monitoring of the MTX reduction on p-AgSAE. Operating parameters of differential pulse voltammetry were optimized and proposed voltammetric method provided high repeatability (relative standard deviation of 11 repeated measurements at concentration level of methotrexate of 1x10-7 mol L-1 equaled to 1.7%), linear concentration range from 5x10-10 to 3x10-6 mol L-1 and low limit of detection (LD = 1.5x10-10 mol L-1). The applicability of proposed method was verified by analysis of real sample of chemotherapeutic preparation. Voltammetric behavior of a wide-spread used chemotherapeutic drug methotrexate (MTX) has been investigated on a polished silver solid amalgam electrode (p-AgSAE) employing various voltammetric methods like cyclic voltammetry, direct current voltammetry and differential pulse voltammetry. It was found that MTX provided two reduction and one oxidation peak in an acidic medium and the positively situated reduction signal (Ep = -340 mV), due its favorable analytical properties, was studied more in detail. 0.05 mol L-1 acetate buffer of pH 5 was selected as an optimal medium for monitoring of the MTX reduction on p-AgSAE. Operating parameters of differential pulse voltammetry were optimized and proposed voltammetric method provided high repeatability (relative standard deviation of 11 repeated measurements at concentration level of methotrexate of 1x10-7 mol L-1 equaled to 1.7%), linear concentration range from 5x10-10 to 3x10-6 mol L-1 and low limit of detection (LD = 1.5x10-10 mol L-1). The applicability of proposed method was verified by analysis of real sample of chemotherapeutic preparation.
dcterms:title
Sensitive voltammetric method for determination of chemotherapeutic drug methotrexate using liquid mercury free silver solid amalgam electrode Sensitive voltammetric method for determination of chemotherapeutic drug methotrexate using liquid mercury free silver solid amalgam electrode
skos:prefLabel
Sensitive voltammetric method for determination of chemotherapeutic drug methotrexate using liquid mercury free silver solid amalgam electrode Sensitive voltammetric method for determination of chemotherapeutic drug methotrexate using liquid mercury free silver solid amalgam electrode
skos:notation
RIV/00216275:25310/14:39898015!RIV15-MSM-25310___
n3:aktivita
n6:P
n3:aktivity
P(EE2.3.30.0021)
n3:cisloPeriodika
září 2014
n3:dodaniDat
n8:2015
n3:domaciTvurceVysledku
n7:3455408 n7:8139199 n7:8356718
n3:druhVysledku
n18:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
44448
n3:idVysledku
RIV/00216275:25310/14:39898015
n3:jazykVysledku
n16:eng
n3:klicovaSlova
determination; silver solid amalgam electrode; voltammetry; methotrexate
n3:klicoveSlovo
n4:silver%20solid%20amalgam%20electrode n4:voltammetry n4:methotrexate n4:determination
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[1000A5DE799C]
n3:nazevZdroje
Scientific Papers of the University of Pardubice, Series A, Faculty of Chemical Technology
n3:obor
n17:CG
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:projekt
n12:EE2.3.30.0021
n3:rokUplatneniVysledku
n8:2014
n3:svazekPeriodika
20
n3:tvurceVysledku
Chýlková, Jaromíra Šelešovská, Renáta Bandžuchová, Lenka
s:issn
1211-5541
s:numberOfPages
16
n14:organizacniJednotka
25310