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Statements

Subject Item
n2:RIV%2F00216275%3A25310%2F13%3A39896543%21RIV14-MZ0-25310___
rdf:type
skos:Concept n8:Vysledek
dcterms:description
A liquid chromatography-tandem mass spectrometry method for the determination of two acetaminophen metabolites, i.e. acetaminophen-glutathione and acetaminophen-cysteine conjugates was developed. The octadecyl silica gel column has been used together with the gradient elution of methanol/water for fast separation of metabolites in less than four minutes. Tandem mass spectrometry in multiple reaction monitoring mode was applied for identification and quantitation of metabolites using deuterated acetaminophen as the internal standard. A liquid chromatography-tandem mass spectrometry method for the determination of two acetaminophen metabolites, i.e. acetaminophen-glutathione and acetaminophen-cysteine conjugates was developed. The octadecyl silica gel column has been used together with the gradient elution of methanol/water for fast separation of metabolites in less than four minutes. Tandem mass spectrometry in multiple reaction monitoring mode was applied for identification and quantitation of metabolites using deuterated acetaminophen as the internal standard.
dcterms:title
Development of LC/MS/MS Method for Determination of Acetaminophen Metabolites Development of LC/MS/MS Method for Determination of Acetaminophen Metabolites
skos:prefLabel
Development of LC/MS/MS Method for Determination of Acetaminophen Metabolites Development of LC/MS/MS Method for Determination of Acetaminophen Metabolites
skos:notation
RIV/00216275:25310/13:39896543!RIV14-MZ0-25310___
n8:predkladatel
n9:orjk%3A25310
n4:aktivita
n15:I n15:S n15:P
n4:aktivity
I, P(NT14320), S
n4:cisloPeriodika
s3
n4:dodaniDat
n13:2014
n4:domaciTvurceVysledku
n7:9887172 n7:3815900 n7:2054744 n7:8169314 n7:7225997 n7:2967391
n4:druhVysledku
n17:J
n4:duvernostUdaju
n19:S
n4:entitaPredkladatele
n6:predkladatel
n4:idSjednocenehoVysledku
69144
n4:idVysledku
RIV/00216275:25310/13:39896543
n4:jazykVysledku
n12:eng
n4:klicovaSlova
porous shell columns; tandem mass spectrometry; liquid chromatography; acetaminophen-glutathione conjugate; acetaminophen
n4:klicoveSlovo
n10:acetaminophen n10:acetaminophen-glutathione%20conjugate n10:liquid%20chromatography n10:porous%20shell%20columns n10:tandem%20mass%20spectrometry
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[F71144BF7BD2]
n4:nazevZdroje
Chemické listy S
n4:obor
n11:CB
n4:pocetDomacichTvurcuVysledku
6
n4:pocetTvurcuVysledku
6
n4:projekt
n18:NT14320
n4:rokUplatneniVysledku
n13:2013
n4:svazekPeriodika
107
n4:tvurceVysledku
Roušar, Tomáš Česla, Petr Vrbová, Martina Nýdlová, Erika Česlová, Lenka Fischer, Jan
s:issn
1803-2389
s:numberOfPages
3
n14:organizacniJednotka
25310