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Statements

Subject Item
n2:RIV%2F00216275%3A25310%2F13%3A39896534%21RIV14-MSM-25310___
rdf:type
skos:Concept n10:Vysledek
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/S0013468613013698
dcterms:description
The detailed electrochemical oxidation and selective determination of fosamprenavir were studied in aqueous-alcohol medium at a carbon paste electrode. Electrochemical behavior of fosamprenavir was investigated as details by different electrochemical techniques in the absence and presence of Triton X-100. The electrochemical mechanism was also carried out and aromatic amine part of the molecule was found to be involved in electrochemical oxidation of fosamprenavir. The oxidized form takes part in hydrolysis; the products are also electroactive and participate in redox reaction. Voltammetric studies were realized between pH 1.0 and 12.0. In the presence of Triton X-100, the signal increased almost 5 times. The promising analytical performance was obtained with developed method. A systematic study of the experimental parameters such as pH, scan rate, accumulation potential and accumulation time that affect the square wave stripping response was carried out and the optimized experimental conditions were arrived. Developed electroanalytical procedure is based on a carbon paste working electrode in Britton-Robinson buffer (pH similar to 2) using square wave voltammetry. Concentration range was linear in the range of 1 x 10(-6)-5 x 10(-5) M fosamprenavir. In sense of low detection limit (4.8 x 10(-7) M) and good repeatability (4.07%) and reproducibility (4.53%) of the results, the method was used for the determination of fosamprenavir in pharmaceutical dosage form successfully. The results are satisfying compared with that of already published high-performance liquid chromatographic results. The detailed electrochemical oxidation and selective determination of fosamprenavir were studied in aqueous-alcohol medium at a carbon paste electrode. Electrochemical behavior of fosamprenavir was investigated as details by different electrochemical techniques in the absence and presence of Triton X-100. The electrochemical mechanism was also carried out and aromatic amine part of the molecule was found to be involved in electrochemical oxidation of fosamprenavir. The oxidized form takes part in hydrolysis; the products are also electroactive and participate in redox reaction. Voltammetric studies were realized between pH 1.0 and 12.0. In the presence of Triton X-100, the signal increased almost 5 times. The promising analytical performance was obtained with developed method. A systematic study of the experimental parameters such as pH, scan rate, accumulation potential and accumulation time that affect the square wave stripping response was carried out and the optimized experimental conditions were arrived. Developed electroanalytical procedure is based on a carbon paste working electrode in Britton-Robinson buffer (pH similar to 2) using square wave voltammetry. Concentration range was linear in the range of 1 x 10(-6)-5 x 10(-5) M fosamprenavir. In sense of low detection limit (4.8 x 10(-7) M) and good repeatability (4.07%) and reproducibility (4.53%) of the results, the method was used for the determination of fosamprenavir in pharmaceutical dosage form successfully. The results are satisfying compared with that of already published high-performance liquid chromatographic results.
dcterms:title
Determination and Detailed Mechanism Study of Antiviral Drug Fosamprenavir Using Carbon Paste Electrode in the Presence of Triton X-100 Determination and Detailed Mechanism Study of Antiviral Drug Fosamprenavir Using Carbon Paste Electrode in the Presence of Triton X-100
skos:prefLabel
Determination and Detailed Mechanism Study of Antiviral Drug Fosamprenavir Using Carbon Paste Electrode in the Presence of Triton X-100 Determination and Detailed Mechanism Study of Antiviral Drug Fosamprenavir Using Carbon Paste Electrode in the Presence of Triton X-100
skos:notation
RIV/00216275:25310/13:39896534!RIV14-MSM-25310___
n10:predkladatel
n11:orjk%3A25310
n3:aktivita
n18:S n18:P n18:I
n3:aktivity
I, P(EE2.3.30.0021), S
n3:cisloPeriodika
říjen
n3:dodaniDat
n12:2014
n3:domaciTvurceVysledku
Ashrafi, Amirmansoor n13:7182554 n13:6345883 n13:6143083
n3:druhVysledku
n14:J
n3:duvernostUdaju
n21:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
68839
n3:idVysledku
RIV/00216275:25310/13:39896534
n3:jazykVysledku
n15:eng
n3:klicovaSlova
pharmaceutics; voltammetry; mechanism; triton X-100; carbon paste electrode; fosamprenavir
n3:klicoveSlovo
n5:pharmaceutics n5:triton%20X-100 n5:voltammetry n5:fosamprenavir n5:mechanism n5:carbon%20paste%20electrode
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[0AC4E034B0F1]
n3:nazevZdroje
Electrochimica Acta
n3:obor
n16:CG
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
8
n3:projekt
n8:EE2.3.30.0021
n3:rokUplatneniVysledku
n12:2013
n3:svazekPeriodika
109
n3:tvurceVysledku
Ozkan, Sibel A. Uslu, Bengi Mikysek, Tomáš Jirásko, Robert Vytřas, Karel Gumustas, Mehmet Nematollahi, Davood Ashrafi, Amirmansoor
n3:wos
000328006300054
s:issn
0013-4686
s:numberOfPages
8
n19:doi
10.1016/j.electacta.2013.07.100
n17:organizacniJednotka
25310