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Statements

Subject Item
n2:RIV%2F00216275%3A25310%2F12%3A39895001%21RIV13-MSM-25310___
rdf:type
skos:Concept n6:Vysledek
dcterms:description
Background: Heterozygous mutation in the glucocerebrosidase gene lead to an increased risk for and to more severe alpha-synuclein-associated pathology in Parkinson's disease. As both glucocerebrosidase and alpha-synuclein interact with fatty acids, we hypothesized that cerebrospinal fluid fatty acid level are altered in these Parkinson's patients. Methods: Cerebrospinal fluid levels of 13 fatty acids in 8 Parkinson's disease patients with a heterozygous glucocerebrosidase mutation were compared with those of 41 idiopathic Parkinson's disease patients and 30 controls using gas chromatography. Results: Parkinson's disease patients with a heterozygous glucocerebrosidase mutation had lover levels of palmitoleic acid (P= 0.007), oleic (P=0.016), linoleic (P=0.005), arachidonic (P=0.003), eicosapentaeneoic (P=0.003) and docosahexaenoic (P=0.03) acids and lower levels of total fatty acids (P=0.005) compared with both idiopathic Parkinson's disease patients and control subjects. Conclusions: These results suggest that abnormalities of fatty acid metabolism are specifically involved in the pathogenesis of Parkinson's disease associated with a heterozygous glucocerebrosidase mutation Background: Heterozygous mutation in the glucocerebrosidase gene lead to an increased risk for and to more severe alpha-synuclein-associated pathology in Parkinson's disease. As both glucocerebrosidase and alpha-synuclein interact with fatty acids, we hypothesized that cerebrospinal fluid fatty acid level are altered in these Parkinson's patients. Methods: Cerebrospinal fluid levels of 13 fatty acids in 8 Parkinson's disease patients with a heterozygous glucocerebrosidase mutation were compared with those of 41 idiopathic Parkinson's disease patients and 30 controls using gas chromatography. Results: Parkinson's disease patients with a heterozygous glucocerebrosidase mutation had lover levels of palmitoleic acid (P= 0.007), oleic (P=0.016), linoleic (P=0.005), arachidonic (P=0.003), eicosapentaeneoic (P=0.003) and docosahexaenoic (P=0.03) acids and lower levels of total fatty acids (P=0.005) compared with both idiopathic Parkinson's disease patients and control subjects. Conclusions: These results suggest that abnormalities of fatty acid metabolism are specifically involved in the pathogenesis of Parkinson's disease associated with a heterozygous glucocerebrosidase mutation
dcterms:title
Cerebrospinal fluid fatty acid in Glucocerebrosidase-Associated Parkinson's Disease Cerebrospinal fluid fatty acid in Glucocerebrosidase-Associated Parkinson's Disease
skos:prefLabel
Cerebrospinal fluid fatty acid in Glucocerebrosidase-Associated Parkinson's Disease Cerebrospinal fluid fatty acid in Glucocerebrosidase-Associated Parkinson's Disease
skos:notation
RIV/00216275:25310/12:39895001!RIV13-MSM-25310___
n6:predkladatel
n7:orjk%3A25310
n3:aktivita
n18:I n18:S
n3:aktivity
I, S
n3:cisloPeriodika
2
n3:dodaniDat
n4:2013
n3:domaciTvurceVysledku
n16:2747472
n3:druhVysledku
n8:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
126319
n3:idVysledku
RIV/00216275:25310/12:39895001
n3:jazykVysledku
n17:eng
n3:klicovaSlova
alpha-synuclein; mutation; Parkinson disease; glucocerebrosidase gene; polyunsaturated fatty acid; cerebrospinal fluid
n3:klicoveSlovo
n9:Parkinson%20disease n9:cerebrospinal%20fluid n9:polyunsaturated%20fatty%20acid n9:glucocerebrosidase%20gene n9:mutation n9:alpha-synuclein
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[FCF102784226]
n3:nazevZdroje
Movement Disorders
n3:obor
n13:FP
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
11
n3:rokUplatneniVysledku
n4:2012
n3:svazekPeriodika
27
n3:tvurceVysledku
Čegan, Alexander Baur, Stephanie Schleicher, Erwin Hauser, Ann-Kathrin Synofzik, Matthis Srulijes, Karin Deutschle, Christian Schmid, Stefan Maetzler, Walter
s:issn
0885-3185
s:numberOfPages
5
n11:organizacniJednotka
25310