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Statements

Subject Item
n2:RIV%2F00216275%3A25310%2F11%3A39892342%21RIV12-MSM-25310___
rdf:type
skos:Concept n12:Vysledek
dcterms:description
A drug delivery system based on physically cross-linked poly vinyl alcohol (PVA)/chitosan blend hydrogels for the release of sparfloxacin antibiotic as a model for drugs was described. Eco-synthesis in current work is based on synthesizing a hydrogel without using chemical crosslinking agents like in the conventional method. In addition all materials are used are non- toxic, safe, non-carcinogenic and can be accepted by the human body without danger. The swelling behavior was tested to be dependent on pH as temperature as well as time and number of freezing thawing cycles. The physical properties of the hydrogels, such as swelling percent, dissolution percent, gel fraction and mechanical properties was assessed. The antimicrobial activity of hydrogels having different compositions was evaluated for both gram positive and gram negative bacteria. Furthermore, the release of antibiotic from hydrogels prepared using the freeze- thawed process was studied. A drug delivery system based on physically cross-linked poly vinyl alcohol (PVA)/chitosan blend hydrogels for the release of sparfloxacin antibiotic as a model for drugs was described. Eco-synthesis in current work is based on synthesizing a hydrogel without using chemical crosslinking agents like in the conventional method. In addition all materials are used are non- toxic, safe, non-carcinogenic and can be accepted by the human body without danger. The swelling behavior was tested to be dependent on pH as temperature as well as time and number of freezing thawing cycles. The physical properties of the hydrogels, such as swelling percent, dissolution percent, gel fraction and mechanical properties was assessed. The antimicrobial activity of hydrogels having different compositions was evaluated for both gram positive and gram negative bacteria. Furthermore, the release of antibiotic from hydrogels prepared using the freeze- thawed process was studied.
dcterms:title
Eco-Synthesis of PVA/Chitosan Hydrogels for Biomedical Application Eco-Synthesis of PVA/Chitosan Hydrogels for Biomedical Application
skos:prefLabel
Eco-Synthesis of PVA/Chitosan Hydrogels for Biomedical Application Eco-Synthesis of PVA/Chitosan Hydrogels for Biomedical Application
skos:notation
RIV/00216275:25310/11:39892342!RIV12-MSM-25310___
n12:predkladatel
n13:orjk%3A25310
n5:aktivita
n19:I
n5:aktivity
I
n5:cisloPeriodika
4
n5:dodaniDat
n15:2012
n5:domaciTvurceVysledku
n16:6328415 Abdel-Lattif, Abdel-Mohsen
n5:druhVysledku
n8:J
n5:duvernostUdaju
n17:S
n5:entitaPredkladatele
n10:predkladatel
n5:idSjednocenehoVysledku
196022
n5:idVysledku
RIV/00216275:25310/11:39892342
n5:jazykVysledku
n7:eng
n5:klicovaSlova
Sparfloxacin; Hydrogel; Drug delivery Polyvinyl alkohol; Chitosan
n5:klicoveSlovo
n6:Drug%20delivery%20Polyvinyl%20alkohol n6:Sparfloxacin n6:Hydrogel n6:Chitosan
n5:kodStatuVydavatele
DE - Spolková republika Německo
n5:kontrolniKodProRIV
[E45EDCB37E38]
n5:nazevZdroje
Journal of Polymers and the Environment
n5:obor
n18:CC
n5:pocetDomacichTvurcuVysledku
2
n5:pocetTvurcuVysledku
5
n5:rokUplatneniVysledku
n15:2011
n5:svazekPeriodika
19
n5:tvurceVysledku
Abdel-Lattif, Abdel-Mohsen Montaser, A. Aly, A. Hebeish, A. Hrdina, Radim
n5:wos
000297370100022
s:issn
1566-2543
s:numberOfPages
8
n9:doi
10.1007/s10924-011-0334-0
n11:organizacniJednotka
25310