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Statements

Subject Item
n2:RIV%2F00216275%3A25310%2F11%3A39892211%21RIV12-GA0-25310___
rdf:type
skos:Concept n9:Vysledek
dcterms:description
Glucocorticoid drugs are commonly used in the treatment of many acute and chronic inflammatory diseases. However, application of these steroids is limited because of their physico-chemical properties, such as very low water solubility. Glucocorticoids also exhibit serious adverse side effects. Therefore, new drug delivery systems are being developed, with the aim of improving the physicochemical properties of glucocorticoids while avoiding undesirable side effects associated with systemic administration. Here we discuss the design and synthesis of conjugates of prednisolone (PD), methylprednisolone (MPD) and similar glucocorticoids. Glucocorticoid drugs are commonly used in the treatment of many acute and chronic inflammatory diseases. However, application of these steroids is limited because of their physico-chemical properties, such as very low water solubility. Glucocorticoids also exhibit serious adverse side effects. Therefore, new drug delivery systems are being developed, with the aim of improving the physicochemical properties of glucocorticoids while avoiding undesirable side effects associated with systemic administration. Here we discuss the design and synthesis of conjugates of prednisolone (PD), methylprednisolone (MPD) and similar glucocorticoids.
dcterms:title
Recent Advances in the Design and Synthesis of Prednisolone and Methylprednisolone Conjugates Recent Advances in the Design and Synthesis of Prednisolone and Methylprednisolone Conjugates
skos:prefLabel
Recent Advances in the Design and Synthesis of Prednisolone and Methylprednisolone Conjugates Recent Advances in the Design and Synthesis of Prednisolone and Methylprednisolone Conjugates
skos:notation
RIV/00216275:25310/11:39892211!RIV12-GA0-25310___
n9:predkladatel
n10:orjk%3A25310
n3:aktivita
n16:Z n16:P
n3:aktivity
P(GAP106/11/0058), Z(MSM0021627501)
n3:cisloPeriodika
32
n3:dodaniDat
n6:2012
n3:domaciTvurceVysledku
n4:4978684 n4:8605270 n4:7138512
n3:druhVysledku
n18:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
225893
n3:idVysledku
RIV/00216275:25310/11:39892211
n3:jazykVysledku
n5:eng
n3:klicovaSlova
Prednisolone; Conjugates; methylprednisolone; Glucocorticoid drugs
n3:klicoveSlovo
n11:Glucocorticoid%20drugs n11:methylprednisolone n11:Conjugates n11:Prednisolone
n3:kodStatuVydavatele
AE - Stát Spojené arabské emiráty
n3:kontrolniKodProRIV
[F4E26F2C0F54]
n3:nazevZdroje
Current Pharmaceutical Design
n3:obor
n20:CC
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:projekt
n17:GAP106%2F11%2F0058
n3:rokUplatneniVysledku
n6:2011
n3:svazekPeriodika
17
n3:tvurceVysledku
Imramovský, Aleš Bílková, Eliška Sedlák, Miloš
n3:wos
000299637000009
n3:zamer
n19:MSM0021627501
s:issn
1381-6128
s:numberOfPages
19
n13:organizacniJednotka
25310