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Statements

Subject Item
n2:RIV%2F00216275%3A25310%2F10%3A39881874%21RIV11-MSM-25310___
rdf:type
n5:Vysledek skos:Concept
dcterms:description
The determination of selected porphyrins, especially of coproporphyrin I and III is presently the most reliable direct approach to the screening of porphyrias. An HPLC method for the simultaneous measurement of coproporphyrin I and III in urine samples has been developed and evaluated. Separation of coproporphyrin I and III from interfering substances was achieved on reversed phase HPLC with gradient elution and fluorescence detection. Analytical performance of this method is satisfactory for both coproporphyrin I and coproporphyrin III: the intra-assay and inter-assay coefficients of variation were below 10 %. Quantitative recoveries from spiked urine were between 85.0 and 101.1 %. The limit of detection was 3.0 and 2.3 ug/L, respectively. The preliminary reference ranges of coproporphyrin I and III in a group of donors are 5.0 51.6 ug/L (0.59 3.20 ug/mmol of creatinine) and 14.9 65.4 ug/L (0.98 8.21 ug/mmol of creatinine). The presented method is inexpensive and suitable for screening of porphyrias. The determination of selected porphyrins, especially of coproporphyrin I and III is presently the most reliable direct approach to the screening of porphyrias. An HPLC method for the simultaneous measurement of coproporphyrin I and III in urine samples has been developed and evaluated. Separation of coproporphyrin I and III from interfering substances was achieved on reversed phase HPLC with gradient elution and fluorescence detection. Analytical performance of this method is satisfactory for both coproporphyrin I and coproporphyrin III: the intra-assay and inter-assay coefficients of variation were below 10 %. Quantitative recoveries from spiked urine were between 85.0 and 101.1 %. The limit of detection was 3.0 and 2.3 ug/L, respectively. The preliminary reference ranges of coproporphyrin I and III in a group of donors are 5.0 51.6 ug/L (0.59 3.20 ug/mmol of creatinine) and 14.9 65.4 ug/L (0.98 8.21 ug/mmol of creatinine). The presented method is inexpensive and suitable for screening of porphyrias.
dcterms:title
The determination of coproporphyrin I and III in human urine using an HPLC with fluorescence detection The determination of coproporphyrin I and III in human urine using an HPLC with fluorescence detection
skos:prefLabel
The determination of coproporphyrin I and III in human urine using an HPLC with fluorescence detection The determination of coproporphyrin I and III in human urine using an HPLC with fluorescence detection
skos:notation
RIV/00216275:25310/10:39881874!RIV11-MSM-25310___
n3:aktivita
n15:S
n3:aktivity
S
n3:cisloPeriodika
prosinec
n3:dodaniDat
n9:2011
n3:domaciTvurceVysledku
n4:2726955 n4:7332580 n4:3021246 n4:2131188
n3:druhVysledku
n14:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
253737
n3:idVysledku
RIV/00216275:25310/10:39881874
n3:jazykVysledku
n16:eng
n3:klicovaSlova
screening; porphyrias; high-performance liquid chromatography with fluorescence detection; coproporphyrin I and III
n3:klicoveSlovo
n8:coproporphyrin%20I%20and%20III n8:high-performance%20liquid%20chromatography%20with%20fluorescence%20detection n8:porphyrias n8:screening
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[C3541E4C22DC]
n3:nazevZdroje
Scientific Papers of the University of Pardubice, Series A, Faculty of Chemical Technology
n3:obor
n12:CE
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n9:2010
n3:svazekPeriodika
16
n3:tvurceVysledku
Frohlichová, Martina Kanďár, Roman Štramová, Xenie Žáková, Pavla Bencová, Soňa
s:issn
1211-5541
s:numberOfPages
12
n17:organizacniJednotka
25310