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Statements

Subject Item
n2:RIV%2F00216275%3A25310%2F10%3A39881510%21RIV11-MSM-25310___
rdf:type
n12:Vysledek skos:Concept
dcterms:description
Homological series of 14 nonchiral derivates and series of 5 chiral derivates of imidazole were tested in vitro as inhibitors of hydrolysis of acetylcholine using enzyme preparation of acetylcholine esterase from electric eel. The batch stirred reactor at 25°C, pH 8 (phosphate buffer), ionic strength 0.11 M and catalytic activity of the enzyme preparation 0.14 U ml-1 of the reaction mixture were used. The temporal dependences of actual concentrations of acetylcholine, choline and acetic acid were determined by an original HPLC method. For all used inhibitors, these time dependences conform with the probability of more than 90 % to the model of competitive irreversible inhibition. All kinetic constants including k3 defining the rate of inhibition (0.71 - 5.3 M-1 s-1) and qualified estimation of the absolute acetylcholine esterase concentration in the reaction mixture (40 - 110 nM) were determined. Homological series of 14 nonchiral derivates and series of 5 chiral derivates of imidazole were tested in vitro as inhibitors of hydrolysis of acetylcholine using enzyme preparation of acetylcholine esterase from electric eel. The batch stirred reactor at 25°C, pH 8 (phosphate buffer), ionic strength 0.11 M and catalytic activity of the enzyme preparation 0.14 U ml-1 of the reaction mixture were used. The temporal dependences of actual concentrations of acetylcholine, choline and acetic acid were determined by an original HPLC method. For all used inhibitors, these time dependences conform with the probability of more than 90 % to the model of competitive irreversible inhibition. All kinetic constants including k3 defining the rate of inhibition (0.71 - 5.3 M-1 s-1) and qualified estimation of the absolute acetylcholine esterase concentration in the reaction mixture (40 - 110 nM) were determined.
dcterms:title
Inhibition of acetylcholinesterase by 14 achiral and five chiral imidazole derivates Inhibition of acetylcholinesterase by 14 achiral and five chiral imidazole derivates
skos:prefLabel
Inhibition of acetylcholinesterase by 14 achiral and five chiral imidazole derivates Inhibition of acetylcholinesterase by 14 achiral and five chiral imidazole derivates
skos:notation
RIV/00216275:25310/10:39881510!RIV11-MSM-25310___
n3:aktivita
n7:Z
n3:aktivity
Z(MSM0021627502)
n3:cisloPeriodika
15
n3:dodaniDat
n13:2011
n3:domaciTvurceVysledku
n8:6973442 n8:7316771 n8:6965938 n8:2747472
n3:druhVysledku
n11:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
263998
n3:idVysledku
RIV/00216275:25310/10:39881510
n3:jazykVysledku
n16:eng
n3:klicovaSlova
chiral; achiral; imidazoles; inhibition; acetylcholinesterase
n3:klicoveSlovo
n5:imidazoles n5:achiral n5:inhibition n5:chiral n5:acetylcholinesterase
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[0855AD0EA5B7]
n3:nazevZdroje
Bioresource Technology
n3:obor
n4:CF
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n13:2010
n3:svazekPeriodika
101
n3:tvurceVysledku
Čegan, Alexander Komers, Karel Štěpánková, Šárka Kovářová, Markéta
n3:wos
000278035900080
n3:zamer
n10:MSM0021627502
s:issn
0960-8524
s:numberOfPages
3
n18:organizacniJednotka
25310