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Statements

Subject Item
n2:RIV%2F00216275%3A25310%2F10%3A39881357%21RIV11-GA0-25310___
rdf:type
skos:Concept n19:Vysledek
dcterms:description
Polyphenolic compounds occurring in hop extracts and their phases I and II metabolites formed during in vivo rat biotransformation have been analyzed using HPLC/MS/MS with electrospray ionization and QqTOF analyzer. Both ESI polarity modes are used for the determination of molecular weights in the full scan spectra and the structural information in subsequent tandem mass spectra. The emphasis is given on the elemental composition determination of individual metabolites based on accurate masses typically better than 5 ppm even with the external calibration. Advanced software tools are used for the metabolite identification using the comparison of the blank chromatogram with the real incubation sample together with the software prediction and detection of possible metabolites. More than ten compounds originating from the hops are identified in rat feces, two of them belong to phase I metabolites and five compounds are phase II metabolites. Polyphenolic compounds occurring in hop extracts and their phases I and II metabolites formed during in vivo rat biotransformation have been analyzed using HPLC/MS/MS with electrospray ionization and QqTOF analyzer. Both ESI polarity modes are used for the determination of molecular weights in the full scan spectra and the structural information in subsequent tandem mass spectra. The emphasis is given on the elemental composition determination of individual metabolites based on accurate masses typically better than 5 ppm even with the external calibration. Advanced software tools are used for the metabolite identification using the comparison of the blank chromatogram with the real incubation sample together with the software prediction and detection of possible metabolites. More than ten compounds originating from the hops are identified in rat feces, two of them belong to phase I metabolites and five compounds are phase II metabolites.
dcterms:title
Identification of New Phase II Metabolites of Xanthohumol in Rat in vivo Biotransformation of Hop Extracts Using High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry Identification of New Phase II Metabolites of Xanthohumol in Rat in vivo Biotransformation of Hop Extracts Using High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry
skos:prefLabel
Identification of New Phase II Metabolites of Xanthohumol in Rat in vivo Biotransformation of Hop Extracts Using High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry Identification of New Phase II Metabolites of Xanthohumol in Rat in vivo Biotransformation of Hop Extracts Using High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry
skos:notation
RIV/00216275:25310/10:39881357!RIV11-GA0-25310___
n3:aktivita
n4:P n4:Z
n3:aktivity
P(GA203/08/1536), Z(MSM0021627502), Z(MSM6198959216)
n3:cisloPeriodika
25
n3:dodaniDat
n13:2011
n3:domaciTvurceVysledku
n16:4329082 n16:6345883
n3:druhVysledku
n18:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
262711
n3:idVysledku
RIV/00216275:25310/10:39881357
n3:jazykVysledku
n8:eng
n3:klicovaSlova
HPLC/MS/MS; Phenolic compounds; Sulfate; Metabolites; Hop; Xanthohumol
n3:klicoveSlovo
n12:Hop n12:HPLC%2FMS%2FMS n12:Phenolic%20compounds n12:Xanthohumol n12:Sulfate n12:Metabolites
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[CE448FE681BA]
n3:nazevZdroje
Journal of Chromatography A
n3:obor
n17:CB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
5
n3:projekt
n11:GA203%2F08%2F1536
n3:rokUplatneniVysledku
n13:2010
n3:svazekPeriodika
1217
n3:tvurceVysledku
Vrublová, Eva Šimánek, Vilím Holčapek, Michal Jirásko, Robert Ulrichová, Jitka
n3:wos
000278779000018
n3:zamer
n14:MSM0021627502 n14:MSM6198959216
s:issn
0021-9673
s:numberOfPages
9
n10:organizacniJednotka
25310