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Statements

Subject Item
n2:RIV%2F00216275%3A25310%2F09%3A00008574%21RIV10-MSM-25310___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Stearoyl-coenzyme A desaturase 1 (SCD1) catalyzes the limiting step of monounsaturated fatty acid synthesis in humans and is an important player in triglyceride generation. SCD1 has been repeatedly implicated in the pathogenesis of metabolic and inflammatory diseases. Therefore it is of great importance to determine SCD1 activity in human samples. In this study we aimed to evaluate a hepatic SCD1 activity index derived from plasma VLDL triglyceride composition as a tool to estimate hepatic SCD1 expression in humans. Additionally, we further evaluated commonly used fatty acid ratios [elongase, de novo lipogenesis, and delta-5 and delta-6 desaturase] in plasma VLDL and hepatic lipid fractions. Liver biopsies and plasma samples were simultaneously collected from 15 individuals. Plasma VLDL was obtained by ultracentrifugation. Hepatic and plasma VLDL lipids were fractionated by thin-layer chromatography, and the fatty acid composition of each fraction was analyzed by gas chromatography. Stearoyl-coenzyme A desaturase 1 (SCD1) catalyzes the limiting step of monounsaturated fatty acid synthesis in humans and is an important player in triglyceride generation. SCD1 has been repeatedly implicated in the pathogenesis of metabolic and inflammatory diseases. Therefore it is of great importance to determine SCD1 activity in human samples. In this study we aimed to evaluate a hepatic SCD1 activity index derived from plasma VLDL triglyceride composition as a tool to estimate hepatic SCD1 expression in humans. Additionally, we further evaluated commonly used fatty acid ratios [elongase, de novo lipogenesis, and delta-5 and delta-6 desaturase] in plasma VLDL and hepatic lipid fractions. Liver biopsies and plasma samples were simultaneously collected from 15 individuals. Plasma VLDL was obtained by ultracentrifugation. Hepatic and plasma VLDL lipids were fractionated by thin-layer chromatography, and the fatty acid composition of each fraction was analyzed by gas chromatography.
dcterms:title
Hepatic lipid composition and stearoyl-coenzyme A desaturase 1 mRNA expression can be estimated from plasma VLDL fatty acid ratios Hepatic lipid composition and stearoyl-coenzyme A desaturase 1 mRNA expression can be estimated from plasma VLDL fatty acid ratios
skos:prefLabel
Hepatic lipid composition and stearoyl-coenzyme A desaturase 1 mRNA expression can be estimated from plasma VLDL fatty acid ratios Hepatic lipid composition and stearoyl-coenzyme A desaturase 1 mRNA expression can be estimated from plasma VLDL fatty acid ratios
skos:notation
RIV/00216275:25310/09:00008574!RIV10-MSM-25310___
n4:aktivita
n8:Z
n4:aktivity
Z(MSM0021627502)
n4:cisloPeriodika
12
n4:dodaniDat
n13:2010
n4:domaciTvurceVysledku
n6:2747472
n4:druhVysledku
n10:J
n4:duvernostUdaju
n9:S
n4:entitaPredkladatele
n18:predkladatel
n4:idSjednocenehoVysledku
316997
n4:idVysledku
RIV/00216275:25310/09:00008574
n4:jazykVysledku
n15:eng
n4:klicovaSlova
stearoyl-coenzyme A desaturase; fatty acids; triglyceride; mRNA; hepatic lipids; VLDL; plasma
n4:klicoveSlovo
n7:hepatic%20lipids n7:triglyceride n7:plasma n7:stearoyl-coenzyme%20A%20desaturase n7:mRNA n7:fatty%20acids n7:VLDL
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[A17E08A42250]
n4:nazevZdroje
Clinical Chemistry
n4:obor
n14:FB
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
2
n4:rokUplatneniVysledku
n13:2009
n4:svazekPeriodika
55
n4:tvurceVysledku
Čegan, Alexander Peter, Andreas
n4:zamer
n12:MSM0021627502
s:issn
0009-9147
s:numberOfPages
8
n17:organizacniJednotka
25310