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Statements

Subject Item
n2:RIV%2F00216275%3A25310%2F07%3A00006515%21RIV08-MSM-25310___
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Background. We studied the relation between plasma total homocysteine and cysteine levels in men with positive and negative angiographic findings. The negative finding was defined as no stenosis in coronary arteries. The positive result was characterized as 70% or more stenosis in coronary arteries or as 50% or more stenosis in arteria coronaria sinistra. Methods. The degree of stenosis was determined by coronary angiography. Both of analytes were measured simultaneously using ion-paired HPLC method with coulometric detection. Results. We compared this method with HPLC method with fluorescence detection by linear regression: HPLC/ED = 1.1435 (HPLC/FD) ? 0.273 umol/l, R2 = 0.9945 for homocysteine and HPLC/ED = 0.8737 (HPLC/FD) + 56.534 umol/l, R2 = 0.8564 for cysteine. The significant positive correlation between levels of cysteine and homocysteine was found in the angiographically negative group (r = 0.506, p = 0.044). In contrast to this finding, there was no significantly correlation in patients Background. We studied the relation between plasma total homocysteine and cysteine levels in men with positive and negative angiographic findings. The negative finding was defined as no stenosis in coronary arteries. The positive result was characterized as 70% or more stenosis in coronary arteries or as 50% or more stenosis in arteria coronaria sinistra. Methods. The degree of stenosis was determined by coronary angiography. Both of analytes were measured simultaneously using ion-paired HPLC method with coulometric detection. Results. We compared this method with HPLC method with fluorescence detection by linear regression: HPLC/ED = 1.1435 (HPLC/FD) ? 0.273 umol/l, R2 = 0.9945 for homocysteine and HPLC/ED = 0.8737 (HPLC/FD) + 56.534 umol/l, R2 = 0.8564 for cysteine. The significant positive correlation between levels of cysteine and homocysteine was found in the angiographically negative group (r = 0.506, p = 0.044). In contrast to this finding, there was no significantly correlation in patients Úvod. Studovali jsme vztah mezi hladinami homocysteinu a cysteinu v plazmě u pacientů s pozitivním a negativním angiografickým nálezem. Negativní nález byl definován jako žádná stenóza ve věnčitých cévách. Pozitivní nález byl charakterizován jako 70% a větší stenóza ve věnčitých cévách nebo jako 50% a větší stenóza v arteria coronaria sinistra. Metody. Stupeň stenózy byl určen pomocí koronární angiografie. Oba analyty byly měřeny simultánně pomocí ion párové chromatografie s coulometrickou detekcí. Výsledky. Pomocí lineární regrese jsme porovnali naši metodu s metodou HPLC s fluorescenční detekcí: HPLC/ED = 1,1435 (HPLC/FD) ? 0,273 umol/l, R2 = 0,9945 pro homocystein a HPLC/ED = 0,8737 (HPLC/FD) + 56,534 umol/l, R2 = 0,8564 pro cystein. U skupiny pacientů s negativním angiografickým nálezem byla nalezena pozitivní korelace mezi hladinami cysteinu a homocysteinu (r = 0,506, p = 0,044), narozdíl od pacientů se stenózou (r = 0,056, p = 0,8287). Prevalence poměru cystein/homocystein, menším než 25, byla
dcterms:title
The relationship between homocysteine and cysteine in patients with different angiographic findings Vztah mezi homocysteinem a cysteinem u pacientů s různými angiografickými nálezy The relationship between homocysteine and cysteine in patients with different angiographic findings
skos:prefLabel
Vztah mezi homocysteinem a cysteinem u pacientů s různými angiografickými nálezy The relationship between homocysteine and cysteine in patients with different angiographic findings The relationship between homocysteine and cysteine in patients with different angiographic findings
skos:notation
RIV/00216275:25310/07:00006515!RIV08-MSM-25310___
n3:strany
S250
n3:aktivita
n8:Z
n3:aktivity
Z(MSM0021627502)
n3:dodaniDat
n7:2008
n3:domaciTvurceVysledku
n4:2726955 n4:2131188
n3:druhVysledku
n12:D
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
447184
n3:idVysledku
RIV/00216275:25310/07:00006515
n3:jazykVysledku
n14:eng
n3:klicovaSlova
homocysteine; cysteine; liquid chromatography with electrochemical detection; angiographic findings
n3:klicoveSlovo
n11:homocysteine n11:angiographic%20findings n11:cysteine n11:liquid%20chromatography%20with%20electrochemical%20detection
n3:kontrolniKodProRIV
[1C5157DB15B7]
n3:mistoVydani
Berlin
n3:nazevZdroje
Clinical Chemistry and Laboratory Medicine
n3:obor
n13:CE
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n7:2007
n3:tvurceVysledku
Myjavec, Andrej Vojtíšek, Petr Žáková, Pavla Stoklasová, Martina Kanďár, Roman
n3:zamer
n6:MSM0021627502
s:issn
1434-6621
s:numberOfPages
1
n16:hasPublisher
Walter de Gruyter GmbH & Co. KG
n15:organizacniJednotka
25310